Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions

被引：33

作者：

Abul Kalam, Mohd ^{[1
]}

Khan, Abdul Arif ^{[1
]}

Alshamsan, Aws ^{[1
]}

Haque, Anzarul ^{[2
]}

Shakeel, Faiyaz ^{[3
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut, Nanomed Res Unit, POB 2457, Riyadh 11451, Saudi Arabia

[2] Prince Sattam bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj, Saudi Arabia

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut, POB 2457, Riyadh 11451, Saudi Arabia

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2018年 / 249卷

关键词：

Activity coefficient; Dissolution thermodynamics; lmmunosuppressant; Molecular interaction; Pure solvent; Solubility; PLUS WATER MIXTURES; DIFFERENT NEAT SOLVENTS; DIFFERENT MONO SOLVENTS; MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; MYCOPHENOLATE-MOFETIL; DIFFERENT TEMPERATURES; 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE; PARAMETERS; CALCIUM;

D O I：

10.1016/j.molliq.2017.11.028

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T = 298.2 K to 318.2 K and pressure p = 0.1 MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28 x 10(-2)) and minimum in water (4.16 x 10(-6)) at "T = 318.2 K" and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：53 / 60

页数：8

共 50 条

[31] Measurement and Correlation of Solubility of Azithromycin Monohydrate in Five Pure Solvents
Wang, Xuemei
Qin, Yanan
Zhang, Tianwei
Tang, Weiwei
Ma, Boai
Gong, Junbo
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2014, 59 (03): : 784 - 791
[32] Measurement and correlation of the solubility of kojic acid in pure and binary solvents
Li, Chang
Ji, Xu
Li, Jiulong
Wu, Di
Qi, Luguang
Wang, Aiyu
Zhou, Lina
Xie, Chuang
Gong, Junbo
Chen, Wei
JOURNAL OF CHEMICAL THERMODYNAMICS, 2022, 167
[33] Measurement and Correlation of the Solubility of Kaempferol Monohydrate in Pure and Binary Solvents
Li, Maolin
Liu, Yumin
Li, Mengya
Shang, Zeren
Liu, Mingdi
Han, Dandan
FLUID PHASE EQUILIBRIA, 2021, 539
[34] Solubility and Solution Thermodynamics of Betaine in Different Pure Solvents and Binary Mixtures
Wang, Shui
Qin, Liying
Zhou, Zhimao
Wang, Jidong
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2012, 57 (08): : 2128 - 2135
[35] Measurement, Correlation, and Thermodynamics of Solubility of Isatin in Nine Different Green Solvents at (298.15 to 338.15) K
Shakeel, Faiyaz
Haq, Nazrul
Iqbal, Muzaffar
Alanazi, Fars K.
Alsarra, Ibrahim A.
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2015, 60 (03): : 801 - 805
[36] Determination and correlation of solubility and solution thermodynamics of musk ketone in twelve pure solvents
Zou, Zongpeng
Sun, Xiaobo
Yu, Yi
Fang, Xin
Xu, Li
JOURNAL OF MOLECULAR LIQUIDS, 2019, 293
[37] Measurement and Correlation of the Solubility of Prednisone Acetate in Different Solvents
Hu, Guoqin
Cui, Leiming
Li, Hua
Li, Huhu
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2011, 56 (05): : 2133 - 2135
[38] Measurement and Correlation of the Solubility for Camptothecine in Different Organic Solvents
Zhi, Juanjuan
Liu, Qiong
Li, Tao
Ren, Baozeng
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2016, 61 (06): : 2052 - 2061
[39] Solubility measurement, correlation and dissolution thermodynamics properties of marbofloxacin in binary solvents
Liu, Huixian
Wu, Zhiying
Yu, Ping
Dong, Zhipeng
Du, Hongxia
Guo, Hongyong
Zhang, Yue
JOURNAL OF MOLECULAR LIQUIDS, 2022, 359
[40] Thermodynamics of risperidone and solubility in pure organic solvents
Mealey, Donal
Svard, Michael
Rasmuson, Ake C.
FLUID PHASE EQUILIBRIA, 2014, 375 : 73 - 79

← 1 2 3 4 5 →