Genetics and infertility II - Affected sib-pair analysis in endometriosis

被引：43
|
作者：
Kennedy, S
Bennett, S
Weeks, DE
机构：
[1] Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford, England
[2] Oxagen Ltd, Oxford, England
[3] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15260 USA
来源：
HUMAN REPRODUCTION UPDATE | 2001年 / 7卷 / 04期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
affected sib-pair analysis; endometriosis; genetics; phenotype-genotype; positional cloning;
D O I：
10.1093/humupd/7.4.411
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.
引用
收藏
页码：411 / 418
页数：8
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