Aryne Reaction and Cross-coupling Approach for the Synthesis of Diverse N-Arylphenylalanine Derivatives

被引：6

作者：

Kobayashi, Tsuneyuki ^{[1
]}

Hosoya, Takamitsu ^{[1
]}

Yoshida, Suguru ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ TMDU, Inst Biomat & Bioengn, Lab Chem Biosci, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan

来源：

CHEMISTRY LETTERS | 2020年 / 49卷 / 07期

关键词：

Aryne; Cross-coupling; Phenylalanine; ALPHA-AMINO-ACID; DIRECT THIOAMINATION; GENERATION; ARYLATION; HALIDES; BOND; FUNCTIONALIZATION; STRATEGY; ESTERS;

D O I：

10.1246/cl.200276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile synthesis of diverse N-arylphenylalanine derivatives is described. We have developed an efficient method for preparing diverse N-arylphenylalanine ester-type platforms containing an aryne generating moiety and a halogen via oxidative cross-coupling. A wide variety of N-arylphenylalanine esters were convergently synthesized using the platforms by a range of aryne reactions and following cross-coupling reactions.

引用

页码：809 / 812

页数：4

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