AMN082, the first selective metabotropic glutaniate receptor subtype 7 agonist: Activation of receptor signaling via an allosteric site in the transmembrane domain

被引：0

作者：

Mitsukawa, K ^{[1
]}

Yamamoto, R ^{[1
]}

Nozulak, J ^{[1
]}

Ofner, S ^{[1
]}

Pescott, O ^{[1
]}

Lukic, S ^{[1
]}

Stoehr, N ^{[1
]}

Urwyler, S ^{[1
]}

Kuhn, R ^{[1
]}

Herrling, P ^{[1
]}

Cryan, JF ^{[1
]}

Flor, PJ ^{[1
]}

机构：

[1] Novartis Pharma AG, Novartis Inst BioMed Res, Neurosci Res, CH-4002 Basel, Switzerland

来源：

NEUROPHARMACOLOGY | 2005年 / 49卷

关键词：

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

087

引用

页码：258 / 258

页数：1

共 42 条

[21] The Antidepressant-Like Action of Metabotropic Glutamate 7 Receptor Agonist N, N′-Bis(Diphenylmethyl)-1,2-Ethanediamine (AMN082) Is Serotonin-Dependent
Palucha-Poniewiera, Agnieszka
Branski, Piotr
Lenda, Tomasz
Pilc, Andrzej
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 334 (03): : 1066 - 1074
[22] Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Gill, JasKiran K.
Savolainen, Mari
Young, Gareth T.
Zwart, Ruud
Sher, Emanuele
Millar, Neil S.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (14) : 5867 - 5872
[23] AMN082, a positive allosteric modulator of the mGlu7 receptor, enhances the antidepressant-like activity of scopolamine in the tail suspension test
Podkowa, K.
Podkowa, A.
Salat, K.
Pilc, A.
Palucha-Poniewiera, A.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2017, 27 : S669 - S669
[24] The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands
Gawel, K.
Jenda-Wojtanowska, M.
Gibula-Bruzda, E.
Kedzierska, E.
Filarowska, J.
Marszalek-Grabska, M.
Wojtanowski, K. K.
Komsta, L.
Talarek, S.
Kotlinska, J. H.
PHYSIOLOGY & BEHAVIOR, 2018, 185 : 112 - 120
[25] AMN082-a metabotropic glutamate receptor type 7 allosteric agonist in the NAc facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats
Vatankhah, Mahsaneh
Sarihi, Abdolrahman
Komaki, Alireza
Shahidi, Siamak
Haghparast, Abbas
BRAIN RESEARCH BULLETIN, 2018, 140 : 28 - 33
[26] Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
Palucha-Poniewiera, Agnieszka
Szewczyk, Bernadeta
Pilc, Andrzej
NEUROPHARMACOLOGY, 2014, 82 : 59 - 68
[27] Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function
Noetzel, Meredith J.
Rook, Jerri M.
Vinson, Paige N.
Cho, Hyekyung P.
Days, Emily
Zhou, Y.
Rodriguez, Alice L.
Lavreysen, Hilde
Stauffer, Shaun R.
Niswender, Colleen M.
Xiang, Zixiu
Daniels, J. Scott
Jones, Carrie K.
Lindsley, Craig W.
Weaver, C. David
Conn, P. Jeffrey
MOLECULAR PHARMACOLOGY, 2012, 81 (02) : 120 - 133
[28] Molecular modeling of the transmembrane domain of mGluR2 metabotropic glutamate receptor and the binding site of its positive allosteric modulators
E. V. Radchenko
D. S. Karlov
V. A. Palyulin
N. S. Zefirov
Doklady Biochemistry and Biophysics, 2014, 454 : 13 - 16
[29] Molecular modeling of the transmembrane domain of mGluR2 metabotropic glutamate receptor and the binding site of its positive allosteric modulators
Radchenko, E. V.
Karlov, D. S.
Palyulin, V. A.
Zefirov, N. S.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2014, 454 (01) : 13 - 16
[30] Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization
Collins, Toby
Young, Gareth T.
Millar, Neil S.
NEUROPHARMACOLOGY, 2011, 61 (08) : 1306 - 1313

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