Synthesis of racemic and enantiomerically pure (R*,R*,R*)-Tris(α-methylbenzyl)phosphane -: X-ray crystal structures of the phosphane oxides and borane complexes

被引：20
|
作者：
Wyatt, P
Eley, H
Charmant, J
Daniel, BJ
Kantacha, A
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[2] Univ Bristol, Struct Chem Lab, Bristol BS8 1TS, Avon, England
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 21期
关键词：
phosphanes; asymmetric synthesis; C-3; symmetry; boranes;
D O I：
10.1002/ejoc.200300396
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric synthesis of C-3-symmetric phosphane 1 has been achieved. Two of the a-methylbenzyl groups were introduced as nucleophiles (using an alpha-methylbenzyl Grignard reagent), and asymmetry was introduced by resolution using (R)-alpha-methylbenzylamine. The final a-methylbenzyl group was introduced as an electrophile (a-methylbenzyl iodide) in a modestly selective reaction. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
引用
收藏
页码：4216 / 4226
页数：11
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