New bisabolane sesquiterpenoids from a marine-derived fungus Aspergillus sp isolated from the sponge Xestospongia testudinaria

被引：54

作者：

Sun, Ling-Ling ^{[1
]}

Shao, Chang-Lun ^{[1
]}

Chen, Jian-Feng ^{[3
]}

Guo, Zhi-Yong ^{[3
]}

Fu, Xiu-Mei ^{[1
]}

Chen, Min ^{[1
]}

Chen, Yi-Yan ^{[1
]}

Li, Rui ^{[1
]}

de Voogd, Nicole J. ^{[4
]}

She, Zhi-Gang ^{[2
]}

Lin, Yong-Cheng ^{[2
]}

Wang, Chang-Yun ^{[1
]}

机构：

[1] Ocean Univ China, Minist Educ China, Sch Med & Pharm, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[3] China Three Gorges Univ, Coll Chem & Life Sci, Yichang 443002, Peoples R China

[4] Netherlands Ctr Biodivers Naturalis, NL-2300 RA Leiden, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Phenolic bisabolane sesquiterpenoid; Marine-derived fungus; Aspergillus sp; Sponge; Cytotoxic activity; SYDONIC ACID; (+)-CURCUPHENOL; METABOLITES;

D O I：

10.1016/j.bmcl.2011.12.083

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new phenolic bisabolane sesquiterpenoid dimers, disydonols A-C (1-3), and one known compound (S)-(+)-sydonol (4) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Their structures were elucidated on the basis of comprehensive spectral analysis including 1D and 2D NMR spectra and HR-ESI-MS. These compounds were evaluated for cytotoxic activity against HepG-2 and Caski human tumour cell lines. Among them, compounds 1 and 3 exhibited cytotoxicity against the two cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1326 / 1329

页数：4

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