Management of Hypersensitivity Reactions to Taxanes

被引：62
|
作者：
Picard, Matthieu [1 ]
机构：
[1] Univ Montreal, Hop Maison Neuve Rosemont, Dept Med, Div Allergy & Immunol, 5415 Blvd Assompt, Montreal, PQ H1T 2M4, Canada
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2017年 / 37卷 / 04期
关键词：
Taxane; Paclitaxel; Docetaxel; Allergy; Hypersensitivity; Skin test; Desensitization and challenge; CUTANEOUS LUPUS-ERYTHEMATOSUS; ALBUMIN-BOUND PACLITAXEL; STEVENS-JOHNSON-SYNDROME; PHASE-II TRIAL; RAPID DESENSITIZATION; NAB-PACLITAXEL; COMPLEMENT ACTIVATION; CROSS-REACTIVITY; FLUID RETENTION; CREMOPHOR-EL;
D O I：
10.1016/j.iac.2017.07.004
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Taxanes are an important class of antineoplastic agents used in the treatment of a wide variety of cancers. However, paclitaxel and docetaxel, which are the most commonly used taxanes, elicit immediate hypersensitivity reactions (HSRs) in 5% to 10% of patients. Almost all patients that experience these reactions can be safely re-exposed to taxanes either through desensitization or challenge. This article describes the clinical presentation, diagnosis, and management of HSRs to taxanes and discusses the different options for their safe readministration.
引用
收藏
页码：679 / +
页数：16
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