Synthesis of substituted 3-trifluoromethylbenzo[b]thiophenes

被引：21
|
作者：
Owton, WM [1 ]
机构：
[1] Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 38期
关键词：
lithiation; trifluoromethylbenzothiophenes;
D O I：
10.1016/S0040-4039(03)01811-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A straightforward method for the synthesis of 5/6-substituted 3-trifluoromethylbenzo[b]thiophenes and their precursor o-fluorinated trifluoro acetophenones is reported. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7147 / 7149
页数：3
相关论文
共 50 条
  • [1] Synthesis of 3-Trifluoromethylbenzo[b]furans from Phenols via Direct Ortho Functionalization by Extended Pummerer Reaction
    Kobatake, Takayuki
    Fujino, Daishi
    Yoshida, Suguru
    Yorimitsu, Hideki
    Oshima, Koichiro
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (34) : 11838 - 11840
  • [2] SYNTHESIS OF SUBSTITUTED BENZO[B]THIOPHENES
    RIED, W
    OREMEK, G
    OCAKCIOGLU, B
    LIEBIGS ANNALEN DER CHEMIE, 1980, (09): : 1424 - 1427
  • [3] One-pot synthesis of 3-trifluoromethylbenzo[b][1,4]oxazines from CF3-imidoyl sulfoxonium ylides with 2-bromophenols
    Pan, Mingshi
    Tong, Yixin
    Qiu, Xiaodong
    Zeng, Xiaobao
    Xiong, Biao
    CHEMICAL COMMUNICATIONS, 2022, 58 (89) : 12443 - 12446
  • [4] 3-SUBSTITUTED THIOPHENES - A STUDY IN SYNTHESIS
    GRONOWITZ, S
    ARKIV FOR KEMI, 1955, 8 (05): : 441 - 448
  • [5] A NEW SYNTHESIS OF NON-SUBSTITUTED BENZO[B]THIOPHENES AND NAPHTHO[2,1-B]THIOPHENES
    BAUER, LN
    YERMILOVA, YV
    AKSENOV, VS
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1983, (01): : 123 - 124
  • [6] Synthesis, polymerization and characterization of substituted dithieno[3,4-b:3′,4′-d]thiophenes
    Inaoka, S
    Collard, DM
    JOURNAL OF MATERIALS CHEMISTRY, 1999, 9 (08) : 1719 - 1725
  • [7] Synthesis of substituted 2-mercaptobenzaldehydes and 2-substituted benzo[b]thiophenes
    Gallagher, T
    Pardoe, DA
    Porter, RA
    TETRAHEDRON LETTERS, 2000, 41 (28) : 5415 - 5418
  • [8] SYNTHESIS AND POLYMERIZATION OF THIOPHENES 3-SUBSTITUTED BY CHIRAL CHAINS
    SCHULZ, E
    BETHMONT, V
    FAHMI, K
    FACHE, F
    LEMAIRE, M
    JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE, 1995, 92 (04) : 783 - 786
  • [9] SYNTHESIS OF 3-SUBSTITUTED BENZO[b]THIOPHENES VIA THE REACTION OF α-SUBSTITUTED 2-LITHIO-β-METHOXYSTYRENES WITH SULFUR
    Kobayashi, Kazuhiro
    Nakai, Daisuke
    Fukamachi, Shuhei
    Konishi, Hisatoshi
    HETEROCYCLES, 2010, 81 (07) : 1703 - 1709
  • [10] Straightforward Synthesis of 2-Acetyl-Substituted Benzo[b]thiophenes
    Debray, Julien
    Lemaire, Marc
    Popowycz, Florence
    SYNLETT, 2013, 24 (01) : 37 - 40
12345