Diminished susceptibility to daptomycin accompanied by clinical failure in a patient with methicillin-resistant Staphylococcus aureus Bacteremia

被引：48
|
作者：
Hirschwerk, David
Ginocchio, Christine C.
Bythrow, Maureen
Condon, Susan
机构：
[1] N Shore Univ Hosp, Div Infect Dis, Manhasset, NY 11030 USA
[2] NYU, Sch Med, Dept Med, New York, NY USA
来源：
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2006年 / 27卷 / 03期
关键词：
D O I：
10.1086/502688
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
We cared for a patient with methicillin-resistant Staphylococcus aureus bacteremia who experienced clinical failure with daptomycin. The failure was accompanied by progressive elevation of the daptomycin minimum inhibitory concentration during treatment. DNA fingerprinting confirmed that the minimum inhibitory concentration elevation occurred within the same strain of methicillin-resistant Staphylococcus aureus. This observation provides important new information to clinicians who adopt this promising drug for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus.
引用
收藏
页码：315 / 317
页数：3
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