Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus

被引：193
|
作者：
Hayden, MK
Rezai, K
Hayes, RA
Lolans, K
Quinn, JP
Weinstein, RA
机构：
[1] Rush Univ, Med Ctr, Chicago, IL 60612 USA
[2] Stroger Cook Cty Hosp, Chicago, IL USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 10期
关键词：
D O I：
10.1128/JCM.43.10.5285-5287.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.
引用
收藏
页码：5285 / 5287
页数：3
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