HIV-1 integrase strand transfer inhibitors (INSTIs): Design, synthesis and biological activity

被引：0

作者：

Ferro, S. ^{[1
]}

Barreca, M. L. ^{[1
]}

De Luca, L. ^{[1
]}

Rao, A. ^{[1
]}

Monforte, A. M. ^{[1
]}

Michiels, M.

Witvrouw, M.

Debyser, Z.

Chimirri, A. ^{[1
]}

机构：

[1] Univ Messina, Dip Farmacochim, I-98168 Messina, Italy

来源：

PROCEEDINGS OF THE 5TH JOINT MEETING ON MEDICINAL CHEMISTRY | 2007年

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In recent years a 3D-pharmacophore model has allowed us to rationally design potent INSTIs. On this basis we synthesized a series of new benzylindole derivatives through efficient solution-phase parallel and microwave-assisted syntheses. Biological evaluation of compounds obtained pointed to a potent IN strand-transfer inhibitory activity.

引用

页码：11 / 15

页数：5

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