HIV-1 integrase strand transfer inhibitors (INSTIs): Design, synthesis and biological activity

被引：0
|
作者：
Ferro, S. [1 ]
Barreca, M. L. [1 ]
De Luca, L. [1 ]
Rao, A. [1 ]
Monforte, A. M. [1 ]
Michiels, M.
Witvrouw, M.
Debyser, Z.
Chimirri, A. [1 ]
机构：
[1] Univ Messina, Dip Farmacochim, I-98168 Messina, Italy
来源：
PROCEEDINGS OF THE 5TH JOINT MEETING ON MEDICINAL CHEMISTRY | 2007年
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In recent years a 3D-pharmacophore model has allowed us to rationally design potent INSTIs. On this basis we synthesized a series of new benzylindole derivatives through efficient solution-phase parallel and microwave-assisted syntheses. Biological evaluation of compounds obtained pointed to a potent IN strand-transfer inhibitory activity.
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页码：11 / 15
页数：5
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