Simple alumina-mediated synthesis of 2-(2-hydroxypropan-2-yl)benzofuran-3(2H)-ones

被引：5
|
作者：
Fang, Lizhen [1 ]
Han, Lili [1 ]
Liu, Saisai [1 ]
Li, Huanhuan [1 ]
机构：
[1] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 30期
基金：
中国国家自然科学基金;
关键词：
Aldol reaction; 2-(2-Hydroxypropan-2-yl)benzofuran-3(2H)-one; Alumina; DERIVATIVES; KETONES; ISATIN;
D O I：
10.1016/j.tetlet.2016.06.058
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study, the Aldol condensation between benzofuran-3(2H)-ones and ketones or aldehydes mediated by alumina was developed. This simple protocol facilitated the synthesis of various 2-(2-hydroxypropan-2-yl)benzofuran-3(2H)-ones in moderate-to-high yields under mild conditions. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3315 / 3317
页数：3
相关论文
共 50 条
  • [1] 2-(2-Hydroxypropan-2-yl)-6-(prop-2-ynyloxy)-1-benzofuran-3(2H)-one
    Kinfe, Henok H.
    Belay, Yonas H.
    Phasha, Zanele H.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3379 - +
  • [2] Microwave-Assisted Synthesis of Benzofuran-3(2H)-ones
    Hu, Xiaojing
    Lai, Huimin
    Zhao, Fangfei
    Hu, Shuyu
    Sun, Qianqian
    Fang, Lizhen
    ACTA CHIMICA SLOVENICA, 2019, 66 (03) : 745 - 750
  • [3] Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity
    Ashok, D.
    Ziauddin, M.
    Lakshmi, B. Vijaya
    Sarasija, M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (07) : 1753 - 1757
  • [4] STERIC REQUIREMENTS OF SP2-HYBRIDISED LONE ELECTRON PAIRS .2. CONFORMATIONS OF 2-(PYRIDYLMETHYLENE)-BENZOFURAN-3(2H)-ONES
    KATRITZKY, AR
    KENNEWEL.PD
    SNAREY, M
    JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC, 1968, (05): : 554 - +
  • [5] 2-[4-(2-Hydroxypropan-2-yl)-1H-1,2,3triazol-1-yl] phenol
    Zhang, Li-Li
    Yu, Kai
    Liu, Ling-Ling
    Guo, Dian-Shun
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1262 - +
  • [6] Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol- 4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity
    D. Ashok
    M. Ziauddin
    B. Vijaya Lakshmi
    M. Sarasija
    Russian Journal of General Chemistry, 2016, 86 : 1753 - 1757
  • [7] REACTION OF BENZOFURAZAN OXIDES WITH BENZOFURAN-3(2H)-ONES, AND A NEW SYNTHESIS OF BENZOFURO[2,3-B]QUINOXALINES
    ZAMET, JJ
    HADDADIN, MJ
    ISSIDORIDES, CH
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1974, (14): : 1687 - 1691
  • [8] Highly enantioselective Michael addition reactions of 2-substituted benzofuran-3(2H)-ones to nitroolefins
    Zhang, Zhi-Pei
    Dong, Nan
    Li, Xin
    Cheng, Jin-Pei
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (39) : 9943 - 9947
  • [9] CONVERGENT AND EFFICIENT SYNTHESIS OF SPIRO[BENZOFURAN-3(2H),4'-PIPERIDINES]
    ROSENBERG, SH
    RAPOPORT, H
    JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (01): : 56 - 62
  • [10] Palladium(II)-Catalyzed Synthesis of 2H,3′H-Spiro[benzofuran-3,2′-naphthoquinones]
    Claes, Pieter
    Jacobs, Jan
    Kesteleyn, Bart
    Tuyen Nguyen Van
    De Kimpe, Norbert
    JOURNAL OF ORGANIC CHEMISTRY, 2013, 78 (17): : 8330 - 8339
12345