Synthesis and in vitro evaluation of the anticancer activity of novel fluorinated thiazolo[4,5-d]pyrimidines

被引：52
|
作者：
Fahmy, HTY
Rostom, SAF
Saudi, MN
Zjawiony, JK
Robins, DJ
机构：
[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
[2] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria, Egypt
[3] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
来源：
ARCHIV DER PHARMAZIE | 2003年 / 336卷 / 4-5期
关键词：
thaizole; fluorinated; thiazolo[4,5-d]pyrimidines; anticancer activity;
D O I：
10.1002/ardp.200300734
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of several thiazolo[4,5-d]pyrimidines containing a fluorophenyl moiety substituted at different positions and through different bridges is described. Twenty new compounds were prepared and evaluated for their anticancer activity using the USA-NCl in-vitro screening program. Three compounds were found active and their anticancer activity against 60 human tumor cell lines are described in detail.
引用
收藏
页码：216 / 225
页数：10
相关论文
共 50 条
  • [21] Synthesis and anticancer evaluation of novel 3,5-diaryl-thiazolo[4,5-d]pyrimidin-2-one derivatives
    Becan, Lilianna
    Wagner, Edwin
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (05) : 2376 - 2384
  • [22] Identification of important structural features of thiazolo[4,5-d]pyrimidines required for potent antifungal activity
    Mahesh Chhabria
    Ishwarsinh Rathod
    Khushbu Vala
    Paulomi Patel
    Medicinal Chemistry Research, 2011, 20 : 1450 - 1454
  • [23] Synthesis and anticancer evaluation of novel 3,5-diaryl-thiazolo[4,5-d]pyrimidin-2-one derivatives
    Lilianna Becan
    Edwin Wagner
    Medicinal Chemistry Research, 2013, 22 : 2376 - 2384
  • [24] IDENTIFICATION OF IMPORTANT STRUCTURAL FEATURES OF THIAZOLO[4,5-D]PYRIMIDINES REQUIRED FOR POTENT ANTIFUNGAL ACTIVITY
    Chhabria, Mahesh
    Rathod, Ishwarsinh
    Vala, Khushbu
    Patel, Paulomi
    MEDICINAL CHEMISTRY RESEARCH, 2010, 19 : S98 - S99
  • [25] Synthesis of some 2-imidoylimino-2,3-dihydro-thiazolo[4,5-d]pyrimidines
    Rensky, Mikhail A.
    Zyabrev, Vladimir S.
    ARKIVOC, 2015, : 110 - 120
  • [26] THIAZOLO [4,5-D]PYRIDAZINES .2. THIAZOLO [4,5-D]PYRIDAZINE AND HALOGENATED DERIVATIVES
    ROBBA, M
    LEGUEN, Y
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1971, (04): : 1491 - &
  • [27] Identification of important structural features of thiazolo[4,5-d]pyrimidines required for potent antifungal activity
    Chhabria, Mahesh
    Rathod, Ishwarsinh
    Vala, Khushbu
    Patel, Paulomi
    MEDICINAL CHEMISTRY RESEARCH, 2011, 20 (09) : 1450 - 1454
  • [28] Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole
    Blokhina, Svetlana V.
    Sharapova, Angelica V.
    Ol'khovich, Marina V.
    Doroshenko, Irina A.
    Levshin, Igor B.
    Perlovich, German L.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 40
  • [29] THIAZOLO[4,5-D]PYRIMIDINES .1. SYNTHESIS AND ANTI-HUMAN CYTOMEGALOVIRUS (HCMV) ACTIVITY IN-VITRO OF CERTAIN ALKYL DERIVATIVES
    LEWIS, AF
    REVANKAR, GR
    FENNEWALD, SM
    HUFFMAN, JH
    RANDO, RF
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (02) : 547 - 556
  • [30] POTENTIAL ANTI-MICROBIALS .2. SYNTHESIS AND INVITRO ANTIMICROBIAL EVALUATION OF SOME THIAZOLO[4,5-D]PYRIMIDINES
    BADAWEY, ESAM
    RIDA, SM
    HAZZA, AA
    FAHMY, HTY
    GOHAR, YM
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1993, 28 (02) : 97 - 101
12345