Synthesis of some 2-imidoylimino-2,3-dihydro-thiazolo[4,5-d]pyrimidines

被引：0
|
作者：
Rensky, Mikhail A. [1 ]
Zyabrev, Vladimir S. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine
来源：
ARKIVOC | 2015年
关键词：
1,2,4-Thiadizol-5(2H)-imines; N-(4-amino-5-cyanothiazol-2(3H)-ylidene)amidines; thiazolo[4,5-d]pyrimidines; cycloaddition; substitution; cyclization; SUBSTITUTED 1,2,4-THIADIAZOL-5(2H)-IMINES; CYCLOADDITION; PRODUCTS; SERIES; AGENTS; DESIGN;
D O I：
10.3998/ark.5550190.p008.867
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The paper is concerned with chemistry of thiazolo[4,5-d]pyrimidine derivatives bearing a 1,3-diazapropenylidene fragment at position 2 and an oxygen or a mobile chlorine atom at position 7. These compounds are obtained in three steps: (i) cycloaddition of malononitrile to available 1,2,4-thiadiazol-5(2H)-imines to form N-(4-amino-5-cyanothiazol-2(3H)-ylidene)amidines; (ii) their acylation or condensation with DMF dimethyl acetal followed by; (iii) pyrimidine ring closure.
引用
收藏
页码：110 / 120
页数：11
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