The anaerobic biosynthesis of plasmalogens

被引：27
|
作者：
Goldfine, Howard [1 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA
来源：
FEBS LETTERS | 2017年 / 591卷 / 18期
关键词：
anaerobic; bacteria; biosynthesis; plasmalogen; UNSATURATED FATTY-ACIDS; SUBCLASS-SPECIFIC ALTERATIONS; OXYGEN-DEPENDENT CLEAVAGE; VINYL-ETHER LINKAGE; CLOSTRIDIUM-BUTYRICUM; ENZYMATIC-SYNTHESIS; MEMBRANE BILAYERS; POLAR LIPIDS; ANIMAL-CELLS; ACYL-COA;
D O I：
10.1002/1873-3468.12714
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The biosynthesis of plasmalogens in anaerobic bacteria differs fundamentally from that in animal cells. Firstly, the formation of the alk-1-enyl ether bond in animal cells is oxygen dependent. Secondly, the first step in plasmalogen formation in animal cells is an acylation of dihydroxyacetone phosphate, which has been ruled out as a precursor in anaerobes. In bacteria the alk-1-enyl ether bond is formed after the fully formed acyl glycerolipids are synthesized. Evidence will be presented for the conversion of the sn-1 acyl-linked chain to an O-alk-1-enyl ether by an as yet unknown mechanism.
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页码：2714 / 2719
页数：6
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