The Evaluation of Data Completeness and Image Quality in Multiplexing Multi-Pinhole SPECT

被引:15
|
作者
Van Audenhaege, Karen [1 ]
Vanhove, Christian [1 ]
Vandenberghe, Stefaan [1 ]
Van Holen, Roel [1 ]
机构
[1] Univ Ghent, iMinds Med IT, MEDISIP IBiTech, Dept Elect & Informat Syst, B-9000 Ghent, Belgium
关键词
Collimator; image quality; image sampling; instrumentation; molecular imaging; multiplexing; overlap; pinhole; single photon emission computed tomography (SPECT); system design; SLIT-SLAT COLLIMATOR; SAMPLING COMPLETENESS; RECONSTRUCTION; PROJECTIONS; BIODISTRIBUTION; TOMOGRAPHY; SIMULATION; ARTIFACTS; ALGORITHM; LOFTHOLE;
D O I
10.1109/TMI.2014.2361051
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Multi-pinhole collimators are often used in pre-clinical SPECT systems because they have a better resolution-sensitivity tradeoff than parallel hole collimators when imaging small objects. Most multi-pinhole collimators are designed to allow no or only a limited amount of overlap between the different pinhole projections because the ambiguity introduced by multiplexing pinholes can result in artifacts. The origin of these artifacts is still not fully understood, but previous research has already shown that data incompleteness could be part of the explanation. Therefore, we developed a method to investigate data completeness in multiplexing multi-pinhole systems and showed that a certain activity distribution can be successfully reconstructed when the nonmultiplexed data is complete or when the overlap can be sufficiently de-multiplexed. We validated this method using computer simulated phantom data of different multiplexing systems. We also studied contrast-to-noise and nonprewhitening matched filter signal-to-noise ratio (NPW-SNR) to compare the image quality in a single pinhole system with multiplexing systems. We found that our method can indeed be used to evaluate data completeness in multiplexing systems and found no artifacts in the systems that had complete data. Sensitivity increased significantly with multiplexing but we found only small, nonsignificant differences in contrast-to-noise ratio. However, the NPW-SNR did slightly improve in the multiplexing setups. We conclude that more multiplexing does not necessarily result in more artifacts and that even a high amount of multiplexing can still result in artifact-free images if the nonmultiplexed data is complete or when the overlap can be sufficiently de-multiplexed.
引用
收藏
页码:474 / 486
页数:13
相关论文
共 50 条
  • [41] Multi-Pinhole SPECT Calibration: Influence of Data Noise and Systematic Orbit Deviations
    Zhou, Lin
    Vunckx, Kathleen
    Nuyts, Johan
    [J]. IEEE TRANSACTIONS ON MEDICAL IMAGING, 2011, 30 (10) : 1795 - 1807
  • [42] Time-Multiplexing using a Static Full-Ring Multi-Pinhole Collimator for Brain SPECT
    Van Audenhaege, Karen
    Vandeghinste, Bert
    Vandenberghe, Stefaan
    Van Holen, Roel
    [J]. 2012 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE RECORD (NSS/MIC), 2012, : 3097 - 3100
  • [43] Evaluation of Different Multi-Pinhole Imaging Geometries for SPECT Imaging of Parkinsonian Disorders
    Spilker, Mary E.
    Bal, Girish
    Uribe, Jorge
    Henderson, David
    Thurfjell, Lennart
    Hehir, Cristina Tan
    Tao, Xiaodong
    Can, Ali
    Sarachan, Brion
    Jansen, Floris
    [J]. 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9, 2009, : 3297 - +
  • [44] Reducing Multiplexing Artifacts in Multi-Pinhole SPECT With a Stacked Silicon-Germanium System: A Simulation Study
    Johnson, Lindsay C.
    Shokouhi, Sepideh
    Peterson, Todd E.
    [J]. IEEE TRANSACTIONS ON MEDICAL IMAGING, 2014, 33 (12) : 2342 - 2351
  • [45] Comparison of MAP and OSEM reconstructions for multi-pinhole SPECT
    Feng, Bing
    Austin, Derek
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2012, 53
  • [46] System Design and Performance Evaluation for Cardiac SPECT Imaging with Multi-pinhole Collimator
    Sun, Lifeng
    Lyu, Zhenlei
    Hou, Yansong
    Liu, Wei
    Jiang, Nianming
    Liu, Hui
    Ma, Tianyu
    [J]. Yuanzineng Kexue Jishu/Atomic Energy Science and Technology, 2021, 55 : 407 - 413
  • [47] Multi-pinhole SPECT imaging with silicon strip detectors
    Peterson, Todd E.
    Shokouhi, Sepideh
    Furenlid, Lars R.
    Wilson, Donald W.
    [J]. 2005 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5, 2005, : 2752 - 2756
  • [48] Performance Evaluation of stationary dedicated cardiac SPECT with multi-pinhole collimators: Comparison with conventional SPECT and CZT SPECT
    Wang, Haipeng
    Guo, Feng
    Wang, Xinqiang
    Zhang, Zongyao
    Wang, Daoyu
    Xu, Yingying
    Liu, Yaqiang
    Chen, Si
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2018, 59
  • [49] Effects of focusing in multi-pinhole SPECT with optical image-guided scan planning
    Branderhorst, Woutjan
    Vastenhouw, Brendan
    van der Have, Frans
    Blezer, Erwin
    Beekman, Frederik
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2010, 51
  • [50] Reconstruction of multi-pinhole SPECT data with correction of attenuation, scatter and intrinsic detector resolution
    Feng, Bing
    Bai, Bing
    Smith, Anne M.
    Austin, Derek W.
    Mintzer, Robert A.
    Gregor, Jens
    [J]. 2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11, 2007, : 3482 - +