NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

被引：83
|
作者：
Weide, Timo [2 ]
Saldanha, S. Adrian [1 ]
Minond, Dmitriy [1 ]
Spicer, Timothy P. [1 ]
Fotsing, Joseph R. [2 ]
Spaargaren, Michael [1 ]
Frere, Jean-Marie [3 ]
Bebrone, Carine [3 ]
Sharpless, K. Barry [2 ]
Hodder, Peter S. [1 ]
Fokin, Valery V. [2 ]
机构：
[1] Scripps Res Inst, Translat Res Inst, Jupiter, FL 33458 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[3] Univ Liege, Ctr Prot Engn, B-4000 Liege, Belgium
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2010年 / 1卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Metallo-beta-lactamases; VIM-2; NH-1,2,3-triazole-based inhibitors; bacterial resistance; Escherichia coli;
D O I：
10.1021/ml900022q
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Metallo-beta-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 beta-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the beta-lactam, imipenem, in Escherichia coli.
引用
收藏
页码：150 / 154
页数：5
相关论文
共 50 条
  • [41] Nosocomial outbreak of imipenem-resistant Pseudomonas aeruginosa producing VIM-2 metallo-β-lactamase in a kidney transplantation unit
    Hammami, S.
    Boutiba-Ben Boubaker, I.
    Ghozzi, R.
    Saidani, M.
    Amine, S.
    Ben Redjeb, S.
    DIAGNOSTIC PATHOLOGY, 2011, 6
  • [42] First outbreak of VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa in The Netherlands: microbiology, epidemiology and clinical outcomes
    Van der Bij, A. K.
    Van Mansfeld, R.
    Peirano, G.
    Goessens, W. H. F.
    Severin, J. A.
    Pitout, J. D. D.
    Willems, R.
    Van Westreenen, M.
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (06) : 513 - 518
  • [43] Discovery of [1,2,4]Triazole Derivatives as New Metallo-β-Lactamase Inhibitors
    Yuan, Chen
    Yan, Jie
    Song, Chen
    Yang, Fan
    Li, Chao
    Wang, Cheng
    Su, Huiling
    Chen, Wei
    Wang, Lijiao
    Wang, Zhouyu
    Qian, Shan
    Yang, Lingling
    MOLECULES, 2020, 25 (01):
  • [44] Identification of VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa isolated from dogs with pyoderma and otitis in Korea
    Hyun, Jae-Eun
    Chung, Tae-Ho
    Hwang, Cheol-Yong
    VETERINARY DERMATOLOGY, 2018, 29 (03) : 186 - +
  • [45] First Detection of VIM-2 Metallo-β-Lactamase-Producing Pseudomonas putida in Blattella germanica Cockroaches in an Algerian Hospital
    Loucif, Lotfi
    Cherak, Zineb
    Chamlal, Naima
    Bendjama, Esma
    Gacemi-Kirane, Djamila
    Grainat, Nadia
    Rolain, Jean-Marc
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (08)
  • [46] Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC
    Kwapien, Karolina
    Gavara, Laurent
    Docquier, Jean-Denis
    Berthomieu, Dorothee
    Hernandez, Jean-Francois
    Gresh, Nohad
    JOURNAL OF COMPUTATIONAL CHEMISTRY, 2021, 42 (02) : 86 - 106
  • [47] First report of VIM-2 metallo-β-lactamases producing Pseudomonas aeruginosa isolates in Morocco
    Maroui, Itto
    Barguigua, Abouddihaj
    Aboulkacem, Asmae
    Ouarrak, Khadija
    Sbiti, Mohammed
    Louzi, Housssain
    Timinouni, Mohammed
    Belhaj, Abdelhaq
    JOURNAL OF INFECTION AND CHEMOTHERAPY, 2016, 22 (03) : 127 - 132
  • [48] Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening
    Christopeit, Tony
    Carlsen, Trine Josefine O.
    Helland, Ronny
    Leiros, Hanna-Kirsti S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (21) : 8671 - 8682
  • [49] First Report of an Extensively Drug-Resistant VIM-2 Metallo-β-Lactamase- Producing Brevundimonas diminuta Clinical Isolate
    Almuzara, Marisa N.
    Barberis, Claudia M.
    Rodriguez, Carlos H.
    Famiglietti, Angela M. R.
    Ramirez, Maria S.
    Vay, Carlos A.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (08) : 2830 - 2832
  • [50] 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors
    Verdirosa, Federica
    Gavara, Laurent
    Sevaille, Laurent
    Tassone, Giusy
    Corsica, Giuseppina
    Legru, Alice
    Feller, Georges
    Chelini, Giulia
    Mercuri, Paola Sandra
    Tanfoni, Silvia
    Sannio, Filomena
    Benvenuti, Manuela
    Cerboni, Giulia
    De Luca, Filomena
    Bouajila, Ezeddine
    Hoang, Yen Vo
    Licznar-Fajardo, Patricia
    Galleni, Moreno
    Pozzi, Cecilia
    Mangani, Stefano
    Docquier, Jean-Denis
    Hernandez, Jean-Francois
    CHEMMEDCHEM, 2022, 17 (07)
12345