NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

被引：83

作者：

Weide, Timo ^{[2
]}

Saldanha, S. Adrian ^{[1
]}

Minond, Dmitriy ^{[1
]}

Spicer, Timothy P. ^{[1
]}

Fotsing, Joseph R. ^{[2
]}

Spaargaren, Michael ^{[1
]}

Frere, Jean-Marie ^{[3
]}

Bebrone, Carine ^{[3
]}

Sharpless, K. Barry ^{[2
]}

Hodder, Peter S. ^{[1
]}

Fokin, Valery V. ^{[2
]}

机构：

[1] Scripps Res Inst, Translat Res Inst, Jupiter, FL 33458 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Univ Liege, Ctr Prot Engn, B-4000 Liege, Belgium

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2010年 / 1卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Metallo-beta-lactamases; VIM-2; NH-1,2,3-triazole-based inhibitors; bacterial resistance; Escherichia coli;

D O I：

10.1021/ml900022q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Metallo-beta-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 beta-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the beta-lactam, imipenem, in Escherichia coli.

引用

页码：150 / 154

页数：5

共 50 条

[31] Infrequent Finding of Metallo-β-Lactamase VIM-2 in Carbapenem-Resistant Pseudomonas aeruginosa Strains from Croatia
Sardelic, Sanda
Bedenic, Branka
Colinon-Dupuich, Celine
Orhanovic, Stjepan
Bosnjak, Zrinka
Plecko, Vanda
Cournoyer, Benoit
Rossolini, Gian Maria
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (05) : 2746 - 2749
[32] Characterization of a new integron containing VIM-2, a metallo-β-lactamase gene cassette, in a clinical isolate of Enterobacter cloacae
Jeong, SH
Lee, K
Chong, YS
Yum, JH
Lee, SH
Choi, HJ
Kim, JM
Park, KH
Han, BH
Lee, SW
Jeong, TS
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (02) : 397 - 400
[33] Nosocomial spread of Pseudomonas aeruginosa producing the metallo-β-lactamase VIM-2 in a Spanish hospital:: clinical and epidemiological implications
Pena, C.
Suarez, C.
Tubau, F.
Gutierrez, O.
Dominguez, A.
Oliver, A.
Pujol, M.
Gudiol, F.
Ariza, J.
CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (10) : 1026 - 1029
[34] Nosocomial spread of Pseudomonas aeruginosa isolates expressing the metallo-β-lactamase VIM-2 in a hematology unit of a French Hospital
Aubron, C
Poirel, L
Fortineau, N
Nicolas, P
Collet, L
Nordmann, P
MICROBIAL DRUG RESISTANCE, 2005, 11 (03) : 254 - 259
[35] Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-β-lactamase
Pallecchi, L
Riccio, ML
Docquier, JD
Fontana, R
Rossolini, GM
FEMS MICROBIOLOGY LETTERS, 2001, 195 (02) : 145 - 150
[36] Bio-waste Derived Catalytic Approach Towards NH-1,2,3-Triazole Synthesis
Garg, Anirban
Hazarika, Roktopol
Dutta, Nilakshi
Dutta, Bidyutjyoti
Sarma, Diganta
CHEMISTRYSELECT, 2021, 6 (29): : 7266 - 7270
[37] VIM-12, a novel plasmid-mediated metallo-β-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid
Pournaras, S
Ikonomidis, A
Tzouvelekis, LS
Tokatlidou, D
Spanakis, N
Maniatis, AN
Legakis, NJ
Tsakris, A
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) : 5153 - 5156
[38] Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor
Xiang, Yang
Zhang, Yue-Juan
Ge, Ying
Zhou, Yajun
Chen, Cheng
Wahlgren, Weixiao Yuan
Tan, Xiangshi
Chen, Xi
Yang, Ke-Wu
BIOMOLECULES, 2020, 10 (01)
[39] First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-β-lactamase (VIM-2) in the United States
Lolans, K
Queenan, AM
Bush, K
Sahud, A
Quinn, JP
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) : 3538 - 3540
[40] Nosocomial outbreak of imipenem-resistant Pseudomonas aeruginosa producing VIM-2 metallo-β-lactamase in a kidney transplantation unit
S Hammami
I Boutiba-Ben Boubaker
R Ghozzi
M Saidani
S Amine
S Ben Redjeb
Diagnostic Pathology, 6

← 1 2 3 4 5 →