Rapamycin: The Cure for all that Ails

被引:12
|
作者
Hasty, Paul [1 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, Inst Biotechnol, San Antonio, TX 78245 USA
关键词
LIFE-SPAN; TARGET; MTOR;
D O I
10.1093/jmcb/mjp033
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Target of rapamycin (TOR) signaling stimulates cell growth by regulating protein synthesis in response to a variety of stimuli in a wide range of species and is inhibited by rapamycin, a naturally occurring antifungal compound produced by bacteria and discovered on Easter Island or in the local vernacular, Rapa Nui (rapamycin's namesake). Recently, rapamycin was shown to extend life span for mice, even when administered late in life, suggesting that inhibiting the mammalian TOR pathway may improve health span for people.
引用
收藏
页码:17 / 19
页数:3
相关论文
共 50 条
  • [31] Three Flavorings for a Soup to Cure what Ails Mental Health Services
    Brown, C. Hendricks
    ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH, 2020, 47 (05) : 844 - 851
  • [32] A CURE for What Ails in Cardiac Resynchronization Therapy Defibrillator or Pacemaker Only? COMMENT
    Wu, Katherine C.
    JACC-CARDIOVASCULAR IMAGING, 2020, 13 (04) : 937 - 939
  • [33] OPINION THE USJOBS CRISIS IS URGENT, BUT THERE'S NO SPEEDY CURE FOR WHAT AILS US
    Quick, Becky
    FORTUNE, 2011, 164 (06) : 110 - 110
  • [34] The Quest for Optimal Health Can Education and Training Cure What Ails Us?
    Swarbrick, Peggy
    Hutchinson, Dori
    Gill, Kenneth
    INTERNATIONAL JOURNAL OF MENTAL HEALTH, 2008, 37 (02) : 69 - 88
  • [35] US Health Reform Obama's reform: no cure for what ails us
    Himmelstein, David U.
    Woolhandler, Steffie
    BRITISH MEDICAL JOURNAL, 2010, 340 : c1778
  • [36] Choosing Wisely: Bedrest-A Panacea for All That Ails the Gravida?
    Jain, Venu
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2019, 41 (07) : 971 - 973
  • [37] A CURE-ALL THAT DOESNT CURE ALL - DEUS EX MISSILES
    LUTTWAK, E
    NEW REPUBLIC, 1982, 187 (06) : 16 - 18
  • [38] MISSING THE MARK: GUN CONTROL IS NOT THE CURE FOR WHAT AILS THE US MENTAL HEALTH SYSTEM
    Wolf, Carolyn Reinach
    Rosen, Jamie A.
    JOURNAL OF CRIMINAL LAW & CRIMINOLOGY, 2015, 104 (04): : 851 - 878
  • [39] CURE-ALL
    BRESCIA, W
    PHI DELTA KAPPAN, 1984, 65 (06) : 437 - 437
  • [40] Tetracycline: a cure all?
    Kennedy, Robert
    Alibhai, Mustansir
    Shakib, Kaveh
    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 2014, 52 (04): : 382 - 383