Rapamycin: The Cure for all that Ails

被引:12
|
作者
Hasty, Paul [1 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, Inst Biotechnol, San Antonio, TX 78245 USA
关键词
LIFE-SPAN; TARGET; MTOR;
D O I
10.1093/jmcb/mjp033
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Target of rapamycin (TOR) signaling stimulates cell growth by regulating protein synthesis in response to a variety of stimuli in a wide range of species and is inhibited by rapamycin, a naturally occurring antifungal compound produced by bacteria and discovered on Easter Island or in the local vernacular, Rapa Nui (rapamycin's namesake). Recently, rapamycin was shown to extend life span for mice, even when administered late in life, suggesting that inhibiting the mammalian TOR pathway may improve health span for people.
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页码:17 / 19
页数:3
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