The promise of zebrafish as a chemical screening tool in cancer therapy

被引：18
|
作者：
Xie, Xiayang [1 ]
Ross, James L. [2 ]
Cowell, John K. [1 ]
Teng, Yong [1 ,3 ]
机构：
[1] Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USA
[2] Berry Coll, Dept Chem, Mt Berry, GA 30149 USA
[3] Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2015年 / 7卷 / 11期
关键词：
T-CELL LEUKEMIA; IN-VIVO; EXPOSURE ROUTES; MODEL; ANGIOGENESIS; EXPRESSION; INHIBITOR; MELANOMA; EMBRYOS; TUMORS;
D O I：
10.4155/fmc.15.73
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer progression in zebrafish recapitulates many aspects of human cancer and as a result, zebrafish have been gaining popularity for their potential use in basic and translational cancer research. Human cancer can be modeled in zebrafish by induction using chemical mutagens, xenotransplantation or by genetic manipulation. Chemical screens based on zebrafish cancer models offer a rapid, powerful and inexpensive means of evaluating the potential of suppression or prevention on cancer. The identification of small molecules through such screens will serve as ideal entry points for novel chemical therapies for cancer treatment. This article outlines advances that have been made within the growing field of zebrafish cancer models and presents their advantages for chemical drug screening.
引用
收藏
页码：1395 / 1405
页数：11
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