The promise of zebrafish as a chemical screening tool in cancer therapy

被引：18
|
作者：
Xie, Xiayang [1 ]
Ross, James L. [2 ]
Cowell, John K. [1 ]
Teng, Yong [1 ,3 ]
机构：
[1] Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USA
[2] Berry Coll, Dept Chem, Mt Berry, GA 30149 USA
[3] Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2015年 / 7卷 / 11期
关键词：
T-CELL LEUKEMIA; IN-VIVO; EXPOSURE ROUTES; MODEL; ANGIOGENESIS; EXPRESSION; INHIBITOR; MELANOMA; EMBRYOS; TUMORS;
D O I：
10.4155/fmc.15.73
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer progression in zebrafish recapitulates many aspects of human cancer and as a result, zebrafish have been gaining popularity for their potential use in basic and translational cancer research. Human cancer can be modeled in zebrafish by induction using chemical mutagens, xenotransplantation or by genetic manipulation. Chemical screens based on zebrafish cancer models offer a rapid, powerful and inexpensive means of evaluating the potential of suppression or prevention on cancer. The identification of small molecules through such screens will serve as ideal entry points for novel chemical therapies for cancer treatment. This article outlines advances that have been made within the growing field of zebrafish cancer models and presents their advantages for chemical drug screening.
引用
收藏
页码：1395 / 1405
页数：11
相关论文
共 50 条
  • [21] Conventional cancer therapy: promise broken or promise delayed?
    Tannock, IF
    LANCET, 1998, 351 : 9 - 16
  • [22] EPR HOLDS PROMISE AS CANCER DIAGNOSTIC TOOL
    不详
    CHEMICAL & ENGINEERING NEWS, 1972, 50 (15) : 14 - &
  • [23] AI shows promise for breast cancer screening
    Pisano, Etta D.
    NATURE, 2020, 577 (7788) : 35 - 36
  • [24] Prostate cancer screening: Promise and peril - A review
    Godley, PA
    CANCER DETECTION AND PREVENTION, 1999, 23 (04): : 316 - 324
  • [25] The Yet Unrealized Promise of Ovarian Cancer Screening
    Drescher, Charles W.
    Anderson, Garnet L.
    JAMA ONCOLOGY, 2018, 4 (04) : 456 - 457
  • [26] Precision Screening for Colorectal Cancer: Promise and Challenges
    Doubeni, Chyke A.
    ANNALS OF INTERNAL MEDICINE, 2015, 163 (05) : 390 - 391
  • [27] The Promise of Targeting Macrophages in Cancer Therapy
    Brown, J. Martin
    Recht, Lawrence
    Strober, Samuel
    CLINICAL CANCER RESEARCH, 2017, 23 (13) : 3241 - 3250
  • [28] The promise and reality of cancer gene therapy
    Hall, SJ
    Chen, SH
    Woo, SLC
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : 785 - 789
  • [29] Cancer and Inflammation: Promise for Biologic Therapy
    Demaria, Sandra
    Pikarsky, Eli
    Karin, Michael
    Coussens, Lisa M.
    Chen, Yen-Ching
    El-Omar, Emad M.
    Trinchieri, Giorgio
    Dubinett, Steven M.
    Mao, Jenny T.
    Szabo, Eva
    Krieg, Arthur
    Weiner, George J.
    Fox, Bernard A.
    Coukos, George
    Wang, Ena
    Abraham, Robert T.
    Carbone, Michele
    Lotze, Michael T.
    JOURNAL OF IMMUNOTHERAPY, 2010, 33 (04) : 335 - 351
  • [30] The promise of monoclonal antibodies for the therapy of cancer
    Gutheil, J
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2001, 38 (01) : 1 - 2
12345