Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia

被引：25
|
作者：
Liersch, Ruediger [1 ]
Schliemann, Christoph [1 ]
Bieker, Ralf [1 ]
Hintelmann, Heike [1 ]
Buechner, Thomas [1 ]
Berdel, Wolfgang E. [1 ]
Mesters, Rolf M. [1 ]
机构：
[1] Univ Munster, Dept Med Hematol & Oncol, D-48129 Munster, Germany
来源：
LEUKEMIA RESEARCH | 2008年 / 32卷 / 06期
关键词：
VEGF-C; VEGFR-3; acute myeloid leukaemia; angiogenesis; prognosis;
D O I：
10.1016/j.leukres.2007.10.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Vascular endothelial growth factor-C (VEGF-C) has been shown to promote survival and resistance to chemotherapy of AML-cells in vitro. We investigated the expression of VEGF-C/VEGFR-3 in the bone marrow and pretherapeutic plasma levels of VEGF-C in patients with newly diagnosed AML. Expression of VEGF-C/VEGFR-3 was significantly higher in AML patients than in controls, while circulating levels did not differ. However, VEGF-C/VEGFR-3 expression was not able to predict clinical outcome. In conclusion, AML is associated with an increased expression of VEGF-C/VEGFR-3. Although expression levels display no prognostic significance in our study, strategies targeting the VEGF-C/VEGFR-3-pathway might be a promising treatment approach. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：954 / 961
页数：8
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