Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia

被引：25

作者：

Liersch, Ruediger ^{[1
]}

Schliemann, Christoph ^{[1
]}

Bieker, Ralf ^{[1
]}

Hintelmann, Heike ^{[1
]}

Buechner, Thomas ^{[1
]}

Berdel, Wolfgang E. ^{[1
]}

Mesters, Rolf M. ^{[1
]}

机构：

[1] Univ Munster, Dept Med Hematol & Oncol, D-48129 Munster, Germany

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 06期

关键词：

VEGF-C; VEGFR-3; acute myeloid leukaemia; angiogenesis; prognosis;

D O I：

10.1016/j.leukres.2007.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor-C (VEGF-C) has been shown to promote survival and resistance to chemotherapy of AML-cells in vitro. We investigated the expression of VEGF-C/VEGFR-3 in the bone marrow and pretherapeutic plasma levels of VEGF-C in patients with newly diagnosed AML. Expression of VEGF-C/VEGFR-3 was significantly higher in AML patients than in controls, while circulating levels did not differ. However, VEGF-C/VEGFR-3 expression was not able to predict clinical outcome. In conclusion, AML is associated with an increased expression of VEGF-C/VEGFR-3. Although expression levels display no prognostic significance in our study, strategies targeting the VEGF-C/VEGFR-3-pathway might be a promising treatment approach. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：954 / 961

页数：8

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