Patterns of Hematologic Function and Cytokine Release Syndrome Severity in ALL Patients Receiving CAR-T and TCR-T Therapies Using Pooled Clinical Trial Data

被引:0
|
作者
Agarwal, Vibhu [1 ]
Socolov, Alexandru [1 ]
Buderi, Robert [1 ]
Rusli, Emelly [1 ]
Bouzit, Lilia [1 ]
Talwai, Aniketh [1 ]
Itzkovich, Yahav [1 ]
Galaznik, Aaron [1 ]
Aptekar, Jacob [1 ]
机构
[1] Dassault Systemes Co, Medidata Acorn AI, New York, NY 10017 USA
关键词
D O I
10.1182/blood-2021-149180
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4826
引用
收藏
页数:4
相关论文
共 50 条
  • [41] Metabolic tumor burden and cytokine release syndrome (CRS) in patients with diffuse large cell B lymphoma (DLCBL) treated with CTL019 chimeric antigen receptor -T-cell (CAR-T): preliminary experience
    Mantarro, C.
    Donegani, M.
    Bauckneht, M.
    Raffa, S.
    Chiola, S.
    Miceli, A. A.
    Lanfranchi, F.
    D'Amico, F.
    Sambuceti, G.
    Raiola, A.
    Ghiggi, C.
    Angelucci, E.
    Morbelli, S.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (SUPPL 1) : S540 - S540
  • [42] IS SYSTOLIC AND DIASTOLIC FUNCTION INCLUDING GLOBAL LONGITUDINAL STRAIN BY ECHOCARDIOGRAPHY COMPROMISED IN ADULT PATIENTS TREATED WITH CD19 CAR T-CELL THERAPIES FOR HEMATOLOGICAL MALIGNANCIES IN THOSE THAT DEVELOPED CYTOKINE RELEASE SYNDROME?
    Daryanani, Andres
    Vallejo, Bryan Alexis
    Toro-Manotas, Rafael
    Santos-Patarroyo, Sebastian
    Herrmann, Joerg
    Paludo, Jonas
    Ansell, Stephen
    Lin, Yi
    Villarraga, Hector R.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 81 (08) : 2407 - 2407
  • [43] Management of cytokine release syndrome in adult and pediatric patients undergoing CAR-T cell therapy for hematological malignancies: Recommendation of the French Society of Bone Marrow and cellular Therapy (SFGM-TC)
    Yakoub-Agha, Ibrahim
    Moreau, Anne-Sophie
    Ahmad, Imran
    Borel, Cecile
    Hadhoum, Nawal
    Masouridi-Levrat, Stavroula
    Naudin, Jerome
    Nicolas-Virelizier, Emmanuelle
    Ouachee-Chardin, Marie
    Platon, Lara
    Quessar, Asmaa
    Roth-Guepin, Gabrielle
    Beauvais, Davis
    Baruchel, Andre
    Cornillon, Jerome
    BULLETIN DU CANCER, 2019, 106 (01) : S102 - S109
  • [44] Mechanistic Studies of Cytokine Release Syndrome (CRS) with Roles of Interferon-Gamma (IFN-g) and Tumor Necrosis Factor Alpha (TNF-α) While Maintaining CAR-T Function in Vitro
    Amatya, Parmeshwar N.
    Xiang, Jingyu
    O'Neal, Julie
    Ritchey, Julie K.
    Carter, Alun J.
    Cooper, Matthew L.
    DiPersio, John
    BLOOD, 2023, 142
  • [45] Pre-existing biochemical entities predict severity of cytokine release syndrome in B-cell Lymphoma patients treated with CD19-directed CAR T-cells
    Gupta, Neetu
    Jalota, Akansha
    Hershberger, Courtney E.
    Patel, Manishkumar S.
    Mian, Agrima
    Faruqi, Aiman
    Khademi, Gholamreza
    Rotroff, Daniel M.
    Hill, Brian T.
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [46] Rates of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) from Center for International Blood and Marrow Transplant Research (CIBMTR) data on US subjects (SUBJ) with lymphoma following chimeric antigen receptor T cell therapy (CAR-T).
    Frigault, Matthew J.
    Amoloja, Theresa
    Burke, Lea Micaletti
    Morariu-Zamfir, Rodica
    Bhatt, Valkal
    Bibeau, Kristen
    Tang, Xiao Ying
    Moskop, Amy
    Maziarz, Richard T.
    DiPersio, John F.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [47] Cytokine Release Syndrome after Treatment of Anti-CD19 CAR-T Therapy with IL-6 Knocking Down in Patients with Central Nervous System B-cell Acute Lymphocytic Leukemia
    Mao, Yanqin
    Xu, Xiang
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021, 51 (06): : 790 - 794
  • [48] Phase I clinical trial using a unique immunotherapeutic combination of MUC1-targeted CAR-T cells with PD-1-knockout in the treatment of patients with advanced esophageal cancer
    Chen, Size
    Lin, Yiguang
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [49] Preclinical Assessment of Efficacy and Safety Analysis of CAR-T Cells (ISIKOK-19) Targeting CD19-Expressing B-Cells for the First Turkish Academic Clinical Trial with Relapsed/Refractory ALL and NHL Patients
    Tastan, Cihan
    Kancagi, Derya Dilek
    Turan, Raife Dilek
    Yurtsever, Bulut
    Cakirsoy, Didem
    Abanuz, Selen
    Yilanci, Muhammet
    Seyis, Utku
    Ozer, Samed
    Mert, Selin
    Kayhan, Cavit Kerem
    Tokat, Fatma
    Elmas, Merve Acikel
    Birdogan, Selcuk
    Arbak, Serap
    Yalcin, Koray
    Sezgin, Aslihan
    Kizilkilic, Ebru
    Hemsinlioglu, Cansu
    Ince, Umit
    Ratip, Siret
    Ovali, Ercument
    TURKISH JOURNAL OF HEMATOLOGY, 2020, 37 (04) : 234 - 247
  • [50] AN ECONOMIC MODEL TO ESTIMATE THE COST OF CYTOKINE RELEASE SYNDROME (CRS) AND NEUROLOGIC EVENTS (NE) OBSERVED IN CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPIES ADMINISTERED TO PATIENTS WITH RELAPSED/REFRACTORY (R/R) LARGE B-CELL LYMPHOMA (LBCL)
    Nguyen, A.
    Garcia, J.
    Gitlin, M.
    Jun, M. P.
    VALUE IN HEALTH, 2020, 23 : S42 - S42