Mechanistic Studies of Cytokine Release Syndrome (CRS) with Roles of Interferon-Gamma (IFN-g) and Tumor Necrosis Factor Alpha (TNF-α) While Maintaining CAR-T Function in Vitro

被引：0
|
作者：
Amatya, Parmeshwar N. [1 ]
Xiang, Jingyu [2 ]
O'Neal, Julie [3 ]
Ritchey, Julie K. [3 ]
Carter, Alun J. [4 ]
Cooper, Matthew L. [5 ]
DiPersio, John [6 ]
机构：
[1] Washington Univ, Sch Med, St Louis, IL USA
[2] Washington Univ, Sch Med, St Louis, MO USA
[3] Washington Univ, Div Oncol, Dept Med, Sch Med, St Louis, MO USA
[4] WUGEN, St Louis, MO USA
[5] Wugen Inc, St Louis, MO USA
[6] Washington Univ, Div Oncol, Sch Med, St Louis, MO USA
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-187449
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 14 条
  • [1] EFFECTS OF TUMOR NECROSIS FACTOR-ALPHA (TNF-A) AND INTERFERON-GAMMA (IFN-G) ON THE FUNCTION AND OXIDATIVE BURST METABOLISM OF NEUTROPHILS (PMN)
    MCGUIRE, JP
    ZELIGS, BJ
    BELLANTI, JA
    PEDIATRIC RESEARCH, 1990, 27 (04) : A159 - A159
  • [2] Association of interferon-gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) polymorphisms with susceptibility to vitiligo in Iranian patients
    Reza, Faryabi Mohamad
    Eskandar, Kamali-Sarvestani
    Ali-Mohammad, Namian
    Shima, Shahbaz
    Rahmatolah, Salmanpoor
    CLINICAL BIOCHEMISTRY, 2011, 44 (13) : S298 - S298
  • [3] The Dual PI3Kdg Inhibitor Duvelisib Potently Inhibits Cytokine Release Syndrome (CRS) While Maintaining CAR-T Function
    Amatya, Parmeshwar N.
    Jayasinghe, Reyka G.
    Carter, Alun J.
    Cooper, Matthew L.
    Pachter, Jonathan A.
    DiPersio, John F.
    Ritchey, Julie K.
    BLOOD, 2022, 140 : 12686 - 12687
  • [4] EFFECTS OF INTERFERON-GAMMA (IFN-GAMMA) AND TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) ASSOCIATION IN INTRAPERITONEAL RADIOIMMUNOTHERAPY - STUDIES ON AN IN-VITRO MICROMETASTASIS MODEL
    IMBERTMARCILLE, BM
    BERREUR, M
    THEDREZ, P
    RIET, A
    DEVYS, A
    CHATAL, JF
    PRADAL, G
    ANTI-CANCER DRUG DESIGN, 1995, 10 (06): : 491 - 505
  • [5] Interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) enhance lipopolysaccharide binding to neutrophils via CD14
    Takeshita, S
    Nakatani, K
    Takata, Y
    Kawase, H
    Sekine, I
    Yoshioka, S
    INFLAMMATION RESEARCH, 1998, 47 (03) : 101 - 103
  • [6] Interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) enhance lipopolysaccharide binding to neutrophils via CD14
    S. Takeshita
    K. Nakatani
    Y. Takata
    H. Kawase
    I. Sekine
    S. Yoshioka
    Inflammation Research, 1998, 47 : 101 - 103
  • [7] The Dual PI3Kδγ Inhibitor Duvelisib Potently Inhibits IL-6 Production and Cytokine Release Syndrome (CRS) While Maintaining CAR-T Function in Vitro and In Vivo
    Amatya, Parmeshwar N.
    Carter, Alun J.
    Ritchey, Julie K.
    Niswonger, Jessica
    Cooper, Matthew L.
    Pachter, Jonathan A.
    DiPersio, John F.
    BLOOD, 2020, 136
  • [8] Interferon-gamma (IFN-γ) but not tumor necrosis factor-alpha (TNF-α) concentrations correlate with endotoxin-induced liver injury associated with the spleen
    Deriy, LV
    Beno, DWA
    Kimura, RE
    PEDIATRIC RESEARCH, 2000, 47 (04) : 55A - 55A
  • [9] CYTOTOXICITY TRIGGERING FACTOR (CTF) - A NOVEL T-CELL PRODUCT WHICH TRIGGERS TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA RELEASE BY INTERFERON-GAMMA (IFN-GAMMA) PRIMED HUMAN MONONUCLEAR-CELLS
    KORNBLUTH, RS
    GREGORY, SA
    EDGINGTON, TS
    LYMPHOKINE RESEARCH, 1987, 6 (01): : U128 - U128
  • [10] CYTOKINE-INDUCED CELL-DEATH AND EXPRESSION OF HIV-1 - DO TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND INTERFERON-GAMMA (IFN-GAMMA) SELECTIVELY KILL HIV-INFECTED CELLS
    BISWAS, P
    POLI, G
    ORENSTEIN, JM
    FAUCI, AS
    JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1993, 6 (06): : 694 - 694
12