Refractory CIDP with chronic lymphocytic leukaemia responding to chemoimmunotherapy

被引：1

作者：

Lewis, Dana ^{[1
]}

Osman, Chinar ^{[2
]}

Allen, David ^{[2
]}

Pinto, Ashwin Arnold ^{[2
]}

Duncombe, Andrew ^{[3
]}

Katifi, Haider A. ^{[2
]}

机构：

[1] Southampton Univ Hosp NHS Trust, Dept Med, Southampton, Hants, England

[2] Southampton Univ Hosp NHS Trust, Wessex Neurol Ctr, Southampton, Hants, England

[3] Southampton Univ Hosp NHS Trust, Dept Haematol, Southampton, Hants, England

来源：

PRACTICAL NEUROLOGY | 2021年 / 21卷 / 02期

关键词：

INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY;

D O I：

10.1136/practneurol-2020-002672

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chronic inflammatory demyelinating polyneuropathy (CIDP) has a variable clinical course with 15% remaining refractory to treatment. We report a woman with severe refractory CIDP and coexisting chronic lymphocytic leukaemia (CLL) who improved dramatically after chemoimmunotherapy appropriate for the CLL, including rituximab. A subsequent CIDP relapse after 15 months responded again to similar treatment, and the improvement has been maintained with 3-monthly rituximab infusions as sole ongoing therapy. The case suggests that CIDP refractory to conventional treatment may have associated pathology, in this case haematological malignancy, and that treating the malignancy can effectively treat the CIDP.

引用

页码：143 / 146

页数：4

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