Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis

被引：27

作者：

Lu, Ming-Zhu ^{[1
]}

Ding, Xin ^{[1
]}

Shao, Changdong ^{[1
]}

Hu, Zhengsong ^{[1
]}

Luo, Haiqing ^{[3
]}

Zhi, Sanjun ^{[1
]}

Hu, Huayou ^{[1
]}

Kan, Yuhe ^{[1
]}

Loh, Teck-Peng ^{[2
]}

机构：

[1] Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[3] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 07期

基金：

中国国家自然科学基金;

关键词：

C-H ARYLATION; FUNCTIONALIZATION; SILICON; ARYL; INDOLES; ARYLSILANES; ACCESS; ALKENYLATION; BENZYLATION; ACTIVATION;

D O I：

10.1021/acs.orglett.0c00631

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.

引用

页码：2663 / 2668

页数：6

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