Nitrimines as Reagents for Metal-Free Formal C(sp2)-C(sp2) Cross-Coupling Reactions

被引：12
|
作者：
Angeles-Dunham, Veronica V. [1 ]
Nickerson, David M. [1 ]
Ray, Devin M. [1 ]
Mattson, Anita E. [1 ]
机构：
[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 52期
关键词：
alkenes; cross-coupling; heterocycles; metal-free reactions; nitrimine reagents; UREA ACTIVATION;
D O I：
10.1002/anie.201408613
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nitrimines are employed as powerful reagents for metal-free formal C(sp(2))-C(sp(2)) cross-coupling reactions. The new chemical process is tolerant of a wide array of nitrimine and heterocyclic coupling partners giving rise to the corresponding di- or trisubstituted alkenes, typically in high yield and with high stereoselectivity. This method is ideal for the metal-free construction of heterocycle-containing drug targets, such as phenprocoumon.
引用
收藏
页码：14538 / 14541
页数：4
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