Synthesis of reversible nucleoside amino acid conjugates

被引：0
|
作者：
Sondhi, SM [1 ]
Xie, J
Modak, AS
Bashkin, JK
机构：
[1] Univ Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India
[2] Washington Univ, Dept Chem, St Louis, MO 63130 USA
[3] Monsanto Co, St Louis, MO 63137 USA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1998年 / 37卷 / 11期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general synthetic method to conjugate cysteine-containing peptides to nucleosides via a disulfide link has been developed, using the heterobifunctional reagent N-succinimidyl-3-(2-pyridylthio)propionate(SPDP) and amino-modified nucleosides. Representative compounds based on C-6 modified adenosine, C-5 modified uridine and 2'-deoxyuridine are reported, along with extensive NMR characterizations of these novel nucleosides.
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页码：1097 / 1103
页数：7
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