Synthesis of reversible nucleoside amino acid conjugates

被引：0
|
作者：
Sondhi, SM [1 ]
Xie, J
Modak, AS
Bashkin, JK
机构：
[1] Univ Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India
[2] Washington Univ, Dept Chem, St Louis, MO 63130 USA
[3] Monsanto Co, St Louis, MO 63137 USA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1998年 / 37卷 / 11期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general synthetic method to conjugate cysteine-containing peptides to nucleosides via a disulfide link has been developed, using the heterobifunctional reagent N-succinimidyl-3-(2-pyridylthio)propionate(SPDP) and amino-modified nucleosides. Representative compounds based on C-6 modified adenosine, C-5 modified uridine and 2'-deoxyuridine are reported, along with extensive NMR characterizations of these novel nucleosides.
引用
收藏
页码：1097 / 1103
页数：7
相关论文
共 50 条
  • [21] Synthesis and biological activity of amino acid conjugates of abscisic acid
    Todoroki, Yasushi
    Narita, Kenta
    Muramatsu, Taku
    Shimomura, Hajime
    Ohnishi, Toshiyuki
    Mizutani, Masaharu
    Ueno, Kotomi
    Hirai, Nobuhiro
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (05) : 1743 - 1750
  • [22] SYNTHESIS OF N-(JASMONOYL)AMINO ACID CONJUGATES
    KRAMELL, R
    SCHMIDT, J
    SCHNEIDER, G
    SEMBDNER, G
    SCHREIBER, K
    TETRAHEDRON, 1988, 44 (18) : 5791 - 5807
  • [23] Synthesis and Antiviral Activity of Amino-Acid Conjugates of Glycyrrhetic Acid
    L. A. Baltina
    M. V. Khudobko
    L. R. Mikhailova
    L. A. Baltina
    V. A. Fedorova
    Ya. A. Orshanskaya
    V. V. Zarubaev
    O. I. Kiselev
    Chemistry of Natural Compounds, 2014, 50 : 473 - 477
  • [24] Synthesis and Antiviral Activity of Amino-Acid Conjugates of Glycyrrhetic Acid
    Baltina, L. A., Jr.
    Khudobko, M. V.
    Mikhailova, L. R.
    Baltina, L. A.
    Fedorova, V. A.
    Orshanskaya, Ya. A.
    Zarubaev, V. V.
    Kiselev, O. I.
    CHEMISTRY OF NATURAL COMPOUNDS, 2014, 50 (03) : 473 - 477
  • [25] Synthesis, Characterization and Biological Evaluation of Amino Acid Conjugates of Mefenamic Acid
    Dubey, Nitin
    Jain, Dinesh K.
    Bhadoriya, Upendra S.
    Solanki, Balvant
    ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (03) : 1237 - 1241
  • [26] Design, synthesis, and antitumor activity of bile acid-polyamine-nucleoside conjugates
    Wu, Dimao
    Ji, Sanhao
    Wu, Yan
    Ju, Yong
    Zhao, Yufen
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (11) : 2983 - 2986
  • [27] Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose
    Li, P
    Shaw, BR
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2005, 24 (5-7): : 675 - 678
  • [28] Synthesis of amino acid conjugates of 1,1′-dimethylferrocene:: New chiral conjugates
    Prokopchuk, Demyan E.
    Orlowski, Grzegorz A.
    Kraatz, Heinz-Bernhard
    INORGANICA CHIMICA ACTA, 2008, 361 (05) : 1327 - 1331
  • [29] Corrole and Porphyrin Amino Acid Conjugates: Synthesis and Physicochemical Properties
    Karikis, Kostas
    Georgilis, Evangelos
    Charalambidis, Georgios
    Petrou, Athanasia
    Vakuliuk, Olena
    Chatziioannou, Theodore
    Raptaki, Iliana
    Tsovola, Sofia
    Papakyriacou, Ioanna
    Mitraki, Anna
    Gryko, Daniel T.
    Coutsolelos, Athanassios G.
    CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (32) : 11245 - 11252
  • [30] Synthesis and Antileishmanial activity of Piperoyl-Amino Acid Conjugates
    Singh, Inder Pal
    Jain, Shreyans Kumar
    Kaur, Amandeep
    Singh, Sukhvinder
    Kumar, Rajender
    Garg, Prabha
    Sharma, Shyam Sundar
    Arora, Sunil Kumar
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (08) : 3439 - 3445
12345