Simultaneous determination of ethinylestradiol and levonorgestrel in oral contraceptives by derivative spectrophotometry

被引：38
|
作者：
Berzas, JJ
Rodriguez, J
Castaneda, G
机构：
[1] Departamento de Química Analítica y Tecnología de Alimentos, Facultad de Ciencias, Universidad de Castilla-La Mancha
来源：
ANALYST | 1997年 / 122卷 / 01期
关键词：
ethinylestradiol; levonorgestrel; derivative spectrophotometry; oral contraceptives;
D O I：
10.1039/a604558h
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method for determining ethinylestradiol (ETE) and levonorgestrel (LEV) in mixtures by first-derivative spectrophotometry is described. The procedure does not require any separation step. Measurements are made at the zero-crossing wavelengths and the calibration graphs are linear up to 26 and 33 mu g ml(-1) of ETE and LEV, respectively. The method was applied to the determination of both compounds in five different Spanish commercial low-dose oral contraceptives. Similar results mere obtained by an HPLC method.
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页码：41 / 44
页数：4
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