Simultaneous determination of ethinylestradiol and levonorgestrel in oral contraceptives by derivative spectrophotometry

被引：38
|
作者：
Berzas, JJ
Rodriguez, J
Castaneda, G
机构：
[1] Departamento de Química Analítica y Tecnología de Alimentos, Facultad de Ciencias, Universidad de Castilla-La Mancha
来源：
ANALYST | 1997年 / 122卷 / 01期
关键词：
ethinylestradiol; levonorgestrel; derivative spectrophotometry; oral contraceptives;
D O I：
10.1039/a604558h
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method for determining ethinylestradiol (ETE) and levonorgestrel (LEV) in mixtures by first-derivative spectrophotometry is described. The procedure does not require any separation step. Measurements are made at the zero-crossing wavelengths and the calibration graphs are linear up to 26 and 33 mu g ml(-1) of ETE and LEV, respectively. The method was applied to the determination of both compounds in five different Spanish commercial low-dose oral contraceptives. Similar results mere obtained by an HPLC method.
引用
收藏
页码：41 / 44
页数：4
相关论文
共 50 条
  • [1] Simultaneous Determination of Ethinylestradiol and Gestodene in Oral Contraceptives by Derivative Spectrophotometry
    Berzas, Nevado, J. J.
    Rodriguez Flores, J.
    Casta QQ eda Pe QQ alvo, G.
    Guzman Bernardo, F. J.
    Analytical Letters, 30 (12):
  • [2] Simultaneous determination of ethinylestradiol and gestodene in oral contraceptives by derivative spectrophotometry
    Nevado, JJB
    Flores, JR
    Penalvo, GC
    Bernardo, FJG
    ANALYTICAL LETTERS, 1997, 30 (12) : 2221 - 2233
  • [3] Simultaneous determination of cyproterone acetate and ethinylestradiol in tablets by derivative spectrophotometry
    Sour, E
    Jalalizadeh, H
    Farsam, H
    Ghadiri, R
    Amanlou, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (08) : 949 - 951
  • [4] Application of H-point standard additions method for simultaneous determination of levonorgestrel and ethinylestradiol in oral contraceptives LD
    Sohrabi M.R.
    Emrarian M.
    Javanbakht M.
    Journal of Applied Sciences, 2010, 10 (16) : 1802 - 1805
  • [5] INFLUENCE OF ETHINYLESTRADIOL-CONTAINING COMBINATION ORAL-CONTRACEPTIVES WITH GESTODENE OR LEVONORGESTREL
    BALOGH, A
    KLINGER, G
    HENSCHEL, L
    BORNER, A
    VOLLANTH, R
    KUHNZ, W
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 48 (02) : 161 - 166
  • [6] DETERMINATION OF ETHINYLESTRADIOL IN THE PRESENCE OF NORETHISTERONE BY DERIVATIVE-DIFFERENCE SPECTROPHOTOMETRY
    KORANY, MA
    ELYAZBI, FA
    ABDELRAZAK, O
    ELSAYED, MA
    PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1985, 7 (04) : 163 - 166
  • [7] Safety, efficacy and patient satisfaction with continuous daily administration of levonorgestrel/ethinylestradiol oral contraceptives
    Benagiano, Giuseppe
    Carrara, Sabina
    Filippi, Valentina
    PATIENT PREFERENCE AND ADHERENCE, 2009, 3 : 131 - 143
  • [8] Determination of ethinylestradiol and gestodene in oral contraceptives by micellar electrokinetic chromatography
    Berzas, JJ
    Rodríguez, J
    Castañeda, G
    Pinilla, MJ
    CHROMATOGRAPHIA, 1999, 49 (1-2) : 65 - 70
  • [9] Determination of ethinylestradiol and gestodene in oral contraceptives by micellar electrokinetic chromatography
    J. J. Berzas
    J. Rodríguez
    G. Castañeda
    M. J. Pinilla
    Chromatographia, 1999, 49 : 65 - 70
  • [10] PARALLEL DETERMINATION OF DESOGESTREL AND 17α-ETHINYLESTRADIOL IN PHARMACEUTICAL FORMULATION BY DERIVATIVE SPECTROPHOTOMETRY
    Ines Toral, M.
    Nacaratte, Fallon
    Nova-Ramirez, Francisca
    Otipka, Romina
    JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2013, 58 (02): : 1779 - 1784
12345