Amyloid-β and tau PET scans predict clinical progression in cognitively unimpaired people

被引：2
|
作者：
Ossenkoppele, Rik [1 ]
Hansson, Oskar [1 ]
Hampel, Harald [2 ]
机构：
[1] Lund Univ, Clin Memory Res Unit, Lund, Sweden
[2] Eisai Inc, Nutley, NJ USA
来源：
NATURE MEDICINE | 2022年 / 28卷 / 11期
关键词：
D O I：
10.1038/s41591-022-02071-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Evidence — provided by a combination of amyloid-β and tau PET examinations — of advanced Alzheimer’s disease pathological changes in the brain in cognitively unimpaired individuals is strongly associated with short-term (3–5 years) cognitive decline. Thus, amyloid-β and tau PET have high clinical relevance.
引用
收藏
页码：2267 / 2268
页数：2
相关论文
共 50 条
  • [21] Comparison of plasma biomarkers and amyloid PET for predicting memory decline in cognitively unimpaired individuals
    Jack, Clifford R.
    Wiste, Heather J.
    Algeciras-Schimnich, Alicia
    Weigand, Stephen D.
    Figdore, Dan J.
    Lowe, Val J.
    Vemuri, Prashanthi
    Graff-Radford, Jonathan
    Ramanan, Vijay K.
    Knopman, David S.
    Mielke, Michelle M.
    Machulda, Mary M.
    Fields, Julie
    Schwarz, Christopher G.
    Cogswell, Petrice M.
    Senjem, Matthew L.
    Therneau, Terry M.
    Petersen, Ronald C.
    ALZHEIMERS & DEMENTIA, 2024, 20 (03) : 2143 - 2154
  • [22] Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score
    Tomassen, Jori
    den Braber, Anouk
    van der Lee, Sven J.
    Reus, Lianne M.
    Konijnenberg, Elles
    Carter, Stephen F.
    Yaqub, Maqsood
    van Berckel, Bart N. M.
    Collij, Lyduine E.
    Boomsma, Dorret I.
    de Geus, Eco J. C.
    Scheltens, Philip
    Herholz, Karl
    Tijms, Betty M.
    Visser, Pieter Jelle
    BMC NEUROLOGY, 2022, 22 (01)
  • [23] Discordant low amyloid-β PET and high neocortical tau PET retention
    Krishnadas, Natasha
    Dore, Vincent
    Lamb, Fiona
    Tyrrell, Regan
    Bozinovski, Svetlana
    Villemagne, Victor
    Rowe, Christopher
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62
  • [24] Neurofilament Light Chain, Tau-PET And Microglia-PET Predict Clinical Progression In Amyloid-Negative Corticobasal Syndrome
    Palleis, C.
    Franzmeier, N.
    Weidinger, E.
    Katzdobler, S.
    Albert, N.
    Sabri, O.
    Barthel, H.
    Rupprecht, R.
    Rauchmann, B. S.
    Perneczky, R.
    Haass, C.
    Levin, J.
    Brendel, M.
    Hoeglinger, G. U.
    MOVEMENT DISORDERS, 2023, 38 : S89 - S90
  • [25] Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults
    Lowe, Val J.
    Bruinsma, Tyler J.
    Wiste, Heather J.
    Min, Hoon-Ki
    Weigand, Stephen D.
    Fang, Ping
    Senjem, Matthew L.
    Therneau, Terry M.
    Boeve, Bradley F.
    Josephs, Keith A.
    Pandey, Mukesh K.
    Murray, Melissa E.
    Kantarci, Kejal
    Jones, David T.
    Vemuri, Prashanthi
    Graff-Radford, Jonathan
    Schwarz, Christopher G.
    Machulda, Mary M.
    Mielke, Michelle M.
    Roberts, Rosebud O.
    Knopman, David S.
    Petersen, Ronald C.
    Jack, Clifford R., Jr.
    NEUROLOGY, 2019, 93 (01) : E29 - E39
  • [26] Amyloid-β and Hyperphosphorylated tau Synergy Drives Clinical Progression in Individuals with Mild Cognitive Impairment
    Pascoal, Tharick
    Benedet, Andrea
    Mathotaarachchi, Sulantha
    Soucy, Jean-Paul
    Beaudry, Tom
    Gauthier, Serge
    Neto, Pedro Rosa
    NEUROLOGY, 2016, 86
  • [27] Exploring the Association between Amyloid-β and Memory Markers for Alzheimer's Disease in Cognitively Unimpaired Older Adults
    Parra, Mario A.
    Gazes, Y.
    Habeck, C.
    Stern, Y.
    JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2024, 11 (02): : 339 - 347
  • [28] Exploring the Association between Amyloid-β and Memory Markers for Alzheimer’s Disease in Cognitively Unimpaired Older Adults
    Mario A. Parra
    Y. Gazes
    C. Habeck
    Y. Stern
    The Journal of Prevention of Alzheimer's Disease, 2024, 11 : 339 - 347
  • [29] Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults
    Arenaza-Urquijo, Eider M.
    Przybelski, Scott A.
    Machulda, Mary M.
    Knopman, David S.
    Lowe, Val J.
    Mielke, Michelle M.
    Reddy, Ashritha L.
    Geda, Yonas E.
    Jack, Clifford R., Jr.
    Petersen, Ronald C.
    Vemuri, Prashanthi
    NEUROLOGY, 2020, 94 (15) : E1571 - E1579
  • [30] Amyloid- and tau-PET imaging in a familial prion kindred
    Jones, David T.
    Townley, Ryan A.
    Graff-Radford, Jonathan
    Botha, Hugo
    Knopman, David S.
    Petersen, Ronald C.
    Jack, Clifford R., Jr.
    Lowe, Val J.
    Boeve, Bradley F.
    NEUROLOGY-GENETICS, 2018, 4 (06)
12345