Extractive spectrophotometric determination of fluconazale by ion-pair cornplex formation with bromocresol green

被引：3
|
作者：
Jalali, Fahimeh [1 ]
Rajabi, Mohammad J. [1 ]
机构：
[1] Razi Univ, Fac Sci, Dept Chem, Kermanshah, Iran
来源：
CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 09期
关键词：
fluconazole; solvent extraction; spectrophotometry; capsule; blood serum;
D O I：
10.1002/cjoc.200790241
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An extraction-spectrophotometric method for the determination of trace amounts of fluconazole was described. Fluconazole was effectively extracted as a I : I ion-pair complex with bromocresole green (BCG) at pH 3.0 into chloroform, followed by spectrophotometric determination at 420 run. Beer's law was obeyed over the range of 450 mu g center dot mL(-1) of fluconazole with a detection limit of 3.7 mu g center dot mL(-1). The method is simple, rapid and sensitive. The procedure was applied to the determination of fluconazole in pharmaceutical preparations as well as its recovery from a blood serum sample.
引用
收藏
页码：1300 / 1303
页数：4
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