Synthesis, Characterization and Biological Evaluation of New 5-aryl-4-methyl-2-[para-(phenylsulfonyl)phenyl]oxazoles

被引：0

作者：

Apostol, Theodora-Venera ^{[1
]}

Draghici, Constantin ^{[2
]}

Dinu, Mihaela ^{[2
]}

Barbuceanu, Stefania-Felicia ^{[1
]}

Socea, Laura Ileana ^{[1
]}

Saramet, Ioana ^{[1
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Organ Chem, Bucharest 020956, Romania

[2] Acad Romana, Ctr Organ Chem CD Nenitzescu, Bucharest 060023, Romania

来源：

REVISTA DE CHIMIE | 2011年 / 62卷 / 02期

关键词：

N-acyl-aminoacid; alpha-acylaminoketone; 1,3-oxazole; 5(4H)-oxazolone; acylaminoacylation; plant-growth regulating effect; ACID AMIDE HYDROLASE; FRIEDEL-CRAFTS REACTION; OXAZOLE SYNTHESIS; THIAZOLE SYNTHESIS; ANTIBACTERIAL ACTIVITY; AROMATIC-HYDROCARBONS; ANTIFUNGAL ACTIVITY; P38; INHIBITORS; AMINO-ACIDS; AMINOKETONE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acylaminoacylation of aromatic hydrocarbons (benzene, toluene, m-xylene) with 4-methyl-2-[4-(phenylsulfonyl)phenyl]oxazol-5(4H)-one in the presence of anhydrous aluminum chloride afforded 2-aza-1,4-diaryl-3-methyl-1,4-butanediones. These new intermediates were cyclized under the action of phosphorus oxychloride to the corresponding 5-aryl-4-methyl-2-[4-(phenylsulfonyl)phenyl]oxazoles. The structures of newly synthesized compounds were confirmed by elemental analysis, FT-IR, UV, H-1- and C-13-NMR. The plant-growth regulating effects of the new compounds were examined. From this biological activity evaluation, it resulted that most compounds shown a weak stimulatory activity at low concentrations.

引用

页码：142 / 148

页数：7

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