Synthesis, Characterization and Biological Evaluation of New 5-aryl-4-methyl-2-[para-(phenylsulfonyl)phenyl]oxazoles

被引：0
|
作者：
Apostol, Theodora-Venera [1 ]
Draghici, Constantin [2 ]
Dinu, Mihaela [2 ]
Barbuceanu, Stefania-Felicia [1 ]
Socea, Laura Ileana [1 ]
Saramet, Ioana [1 ]
机构：
[1] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Organ Chem, Bucharest 020956, Romania
[2] Acad Romana, Ctr Organ Chem CD Nenitzescu, Bucharest 060023, Romania
来源：
REVISTA DE CHIMIE | 2011年 / 62卷 / 02期
关键词：
N-acyl-aminoacid; alpha-acylaminoketone; 1,3-oxazole; 5(4H)-oxazolone; acylaminoacylation; plant-growth regulating effect; ACID AMIDE HYDROLASE; FRIEDEL-CRAFTS REACTION; OXAZOLE SYNTHESIS; THIAZOLE SYNTHESIS; ANTIBACTERIAL ACTIVITY; AROMATIC-HYDROCARBONS; ANTIFUNGAL ACTIVITY; P38; INHIBITORS; AMINO-ACIDS; AMINOKETONE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Acylaminoacylation of aromatic hydrocarbons (benzene, toluene, m-xylene) with 4-methyl-2-[4-(phenylsulfonyl)phenyl]oxazol-5(4H)-one in the presence of anhydrous aluminum chloride afforded 2-aza-1,4-diaryl-3-methyl-1,4-butanediones. These new intermediates were cyclized under the action of phosphorus oxychloride to the corresponding 5-aryl-4-methyl-2-[4-(phenylsulfonyl)phenyl]oxazoles. The structures of newly synthesized compounds were confirmed by elemental analysis, FT-IR, UV, H-1- and C-13-NMR. The plant-growth regulating effects of the new compounds were examined. From this biological activity evaluation, it resulted that most compounds shown a weak stimulatory activity at low concentrations.
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收藏
页码：142 / 148
页数：7
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