Michael addition reactions of acetoacetates and malonates with acrylates in water under strongly alkaline conditions

被引：10

作者：

Iwamura, M ^{[1
]}

Gotoh, Y ^{[1
]}

Hashimoto, T ^{[1
]}

Sakurai, R ^{[1
]}

机构：

[1] Toho Univ, Dept Biomol Sci, Funabashi, Chiba 2748510, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 37期

关键词：

Michael reactions; 5 M KOH aqueous solution; acetoacetate; malonate; acrylate;

D O I：

10.1016/j.tetlet.2005.07.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition reactions of acetoacetates and malonates with acrylates in a 5 M KOH aqueous solution without using any other catalysts are described. When they are either tert-butyl or benzyl esters, the reaction proceeded very rapidly to afford moderate to high yields of the corresponding bis-Michael adducts that are unexpectedly stable under these conditions. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6275 / 6277

页数：3

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