Michael addition reactions of acetoacetates and malonates with acrylates in water under strongly alkaline conditions

被引：10
|
作者：
Iwamura, M [1 ]
Gotoh, Y [1 ]
Hashimoto, T [1 ]
Sakurai, R [1 ]
机构：
[1] Toho Univ, Dept Biomol Sci, Funabashi, Chiba 2748510, Japan
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 37期
关键词：
Michael reactions; 5 M KOH aqueous solution; acetoacetate; malonate; acrylate;
D O I：
10.1016/j.tetlet.2005.07.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Michael addition reactions of acetoacetates and malonates with acrylates in a 5 M KOH aqueous solution without using any other catalysts are described. When they are either tert-butyl or benzyl esters, the reaction proceeded very rapidly to afford moderate to high yields of the corresponding bis-Michael adducts that are unexpectedly stable under these conditions. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6275 / 6277
页数：3
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