Novel application of Leuckart-Wallach reaction for synthesis of tetrahydro-1,4-benzodiazepin-5-ones library

被引：55

作者：

Lee, Sung-Chan ^{[1
]}

Park, Seung Bum ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 36期

关键词：

PHARMACOLOGICAL ACTIVITY; INHIBITORS; DERIVATIVES; BENZODIAZEPINE; ANTHRAMYCIN; DESIGN;

D O I：

10.1039/b709768a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient strategy has been developed to synthesize privileged tetrahydro-1,4-benzodiazepines with excellent yields and purities; this synthetic pathway was established by the revitalization of the Leuckart-Wallach(LW) reaction via solidphase synthesis.

引用

页码：3714 / 3716

页数：3

共 38 条

[31] 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-ones as chiral auxiliaries:: Synthesis and application in the aldol addition reaction and conjugate addition.
Hitchcock, SR
Finefield, J
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U381 - U381
[32] Cycloaddition reaction of benzoheteroazepine:: Synthesis of 4a,5,6,12-tetrahydro-1H-1,3-oxazino[3,2-d][1,5] benzothiazepin-1-ones and 1H,7H-1,3-oxazino[3,2-d][1,5] benzodiazepin-1-ones
Xu, JX
Jin, S
Xing, QY
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1998, 141 : 57 - 70
[33] Synthesis of Novel Tricyclic 4-Chloro-7,8,10,11-tetrahydro-5H-benzo[e]pyrimido[4,5-b][1,4]diazepin-9(6H)-ones
Xiang, Jinbao
Zheng, Lianyou
Zhu, Tong
Dang, Qun
Bai, Xu
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (04) : 990 - 993
[34] Indium Trichloride Catalyzed Diels-Alder Reaction: Synthesis of Novel 5-Butyl-11a-aryl-4a, 5,11,11a-tetrahydro-11bH-indolo[3,2-c] quinoline-1,4-dione
Gupta, Ragini
Jain, Anshu
Madan, Yogita
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (06) : 1342 - 1345
[35] CYCLOMETALLATED DERIVATIVES OF PALLADIUM(II) WITH 1,4-BENZODIAZEPIN-2-ONES - CRYSTAL-STRUCTURE OF (L-H)PD(PPH3)CL.CHCL3 (L = PRAZEPAM-7-CHLORO-1-CYCLOPROPYLMETHYL-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE) - SYNTHESIS OF ISOINDOLO[2,1-D][1,4]BENZODIAZEPINE DERIVATIVES BY REACTION OF [(L-H)PDCL]2 SPECIES WITH CARBON-MONOXIDE
CINELLU, MA
GLADIALI, S
MINGHETTI, G
STOCCORO, S
DEMARTIN, F
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1991, 401 (03) : 371 - 384
[36] ASYMMETRIC-SYNTHESIS OF ANTHRACYCLINONES - SYNTHESIS OF A NEW CHIRAL AB-SYNTHON, (5R,6R)-6-ETHYL-5,6-DIHYDROXY-5,6,7,8-TETRAHYDRO-1,4-NAPHTHOQUINONE, AND ITS APPLICATION FOR A NOVEL REGIOSELECTIVE SYNTHESIS OF (-)-GAMMA-RHODOMYCINONE
FUJIOKA, H
YAMAMOTO, H
ANNOURA, H
MAEDA, H
KITA, Y
CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (01) : 32 - 35
[37] Ionic liquid 1-butyl-3-methylimidazolium bromide: A green reaction media for the efficient synthesis of 3-methyl-1,4-diphenyl-1,4,5,7-tetrahydro-pyrazolo [3,4-d]pyrimidine-6-ones/thiones using phthalimide-N-sulfonic acid as catalyst
Sudhan, S. P. N.
Ahmed, R. Nasir
Kiyani, H.
Mansoor, S. Sheik
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2018, 22 (03) : 269 - 278
[38] SYNTHESIS, REACTIVITY, AND APPLICATION AS CHIRAL AUXILIARIES OF THE NOVEL (3R) AND (3S)-4,5-DIHYDRO-3-HYDROXY-4,4,5,5-TETRAMETHYL-3-PHENYLFURAN-2(3H)-ONES IN THE PATERNO-BUCHI REACTION
OPPENLANDER, T
SCHONHOLZER, P
HELVETICA CHIMICA ACTA, 1989, 72 (08) : 1792 - 1800

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