Three new 2-(2-phenylethyl)chromone derivatives from artificial holing agarwood of Aquilaria sinensis

被引：14

作者：

Kuang, Tong-Dong ^{[1
,2
,3
]}

Chen, Hui-Qin ^{[1
,2
]}

Kong, Fan-Dong ^{[1
,2
]}

Cai, Cai-Hong ^{[1
,2
]}

Yang, Li ^{[1
,2
]}

Mei, Wei-Li ^{[1
,2
]}

Dai, Hao-Fu ^{[1
,2
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China

[2] Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China

[3] Hainan Univ, Hort & Garden Coll, Haikou 570228, Hainan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2018年 / 26卷

关键词：

Aquilaria sinensis; Agarwood; 2-(2-Phenylethyl)chromone derivative; AChE inhibitory activity; CHINESE EAGLEWOOD; ACETYLCHOLINESTERASE; SESQUITERPENOIDS; MALACCENSIS; CHROMONE;

D O I：

10.1016/j.phytol.2018.05.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new 2-(2-phenylethyl)chromone derivatives (1-3) were obtained from the artificial holing agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced by detailed spectroscopic analysis and the absolute configurations were determined by ECD calculations. Compounds 1-3 displayed acetylcholinesterase (AChE) inhibitory activity with the inhibition ratios in the range of 30% 45% at a concentration of 50 mu g/ml.

引用

页码：96 / 100

页数：5

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