Three new 2-(2-phenylethyl)chromone derivatives from artificial holing agarwood of Aquilaria sinensis

被引：14
|
作者：
Kuang, Tong-Dong [1 ,2 ,3 ]
Chen, Hui-Qin [1 ,2 ]
Kong, Fan-Dong [1 ,2 ]
Cai, Cai-Hong [1 ,2 ]
Yang, Li [1 ,2 ]
Mei, Wei-Li [1 ,2 ]
Dai, Hao-Fu [1 ,2 ]
机构：
[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
[2] Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
[3] Hainan Univ, Hort & Garden Coll, Haikou 570228, Hainan, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2018年 / 26卷
关键词：
Aquilaria sinensis; Agarwood; 2-(2-Phenylethyl)chromone derivative; AChE inhibitory activity; CHINESE EAGLEWOOD; ACETYLCHOLINESTERASE; SESQUITERPENOIDS; MALACCENSIS; CHROMONE;
D O I：
10.1016/j.phytol.2018.05.008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new 2-(2-phenylethyl)chromone derivatives (1-3) were obtained from the artificial holing agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced by detailed spectroscopic analysis and the absolute configurations were determined by ECD calculations. Compounds 1-3 displayed acetylcholinesterase (AChE) inhibitory activity with the inhibition ratios in the range of 30% 45% at a concentration of 50 mu g/ml.
引用
收藏
页码：96 / 100
页数：5
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