Concomitant and sequential administration of YM155 and docetaxel enhances apoptosis and tumor regression in human tumor xenograft models

被引:0
|
作者
Yamanaka, Kentaro [1 ]
Nakahara, Takahito [1 ]
Kita, Aya [1 ]
Takeuchi, Masahiro [1 ]
Kinoyama, Isao [1 ]
Matsuhisa, Akira [1 ]
Koutoku, Hiroshi [1 ]
Sasamata, Masao [1 ]
机构
[1] Astellas Pharma Inc, Tsukuba, Japan
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:3520S / 3521S
页数:2
相关论文
共 34 条
  • [21] TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis
    Matsuo, Yo
    Park, Jae-Hyun
    Miyamoto, Takashi
    Yamamoto, Shinji
    Hisada, Shoji
    Alachkar, Houda
    Nakamura, Yusuke
    SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (259) : 259ra145
  • [22] Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models
    Wang, Fen
    Zhu, Yuanfang
    Fang, Shanyu
    Li, Shuya
    Liu, Sisun
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (02) : 1143 - 1148
  • [23] Anti-tumor activity of motesanib diphosphate alone and in combination with docetaxel or tamoxifen in xenograft models of human breast carcinoma
    Coxon, A.
    Bush, T.
    Belmontes, B.
    Suffran, D.
    Ona, V
    Rex, K.
    Caenepeel, S.
    Hughes, P.
    Koifnon, S.
    Radinsky, R.
    Kendall, R.
    Price, J.
    Polverino, A.
    BREAST CANCER RESEARCH AND TREATMENT, 2007, 106 : S77 - S77
  • [24] Fluoxetine inhibits multidrug resistance extrusion pumps and enhances responses to chemotherapy in syngeneic and in human xenograft mouse tumor models
    Peer, D
    Dekel, Y
    Melikhov, D
    Margalit, R
    CANCER RESEARCH, 2004, 64 (20) : 7562 - 7569
  • [25] Sunitinib (SUTENT, SU11248) Suppresses Tumor Growth and Induces Apoptosis in Xenograft Models of Human Hepatocellular Carcinoma
    Huynh, H.
    Ngo, V. C.
    Choo, S. P.
    Poon, D.
    Koong, H. N.
    Thng, C. H.
    Toh, H. C.
    Zheng, L.
    Ong, L. C.
    Jin, Y.
    Song, I. C.
    Chang, A. P. C.
    Ong, H. S.
    Chung, A. Y. F.
    Chow, P. K. H.
    Soo, K. C.
    CURRENT CANCER DRUG TARGETS, 2009, 9 (06) : 738 - 747
  • [26] Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human tumor xenograft models
    Sakamoto, Toshiaki
    Ozaki, Kei-ichi
    Fujio, Kohsuke
    Kajikawa, Shu-hei
    Uesato, Shin-ichi
    Watanabe, Kazushi
    Tanimura, Susumu
    Koji, Takehiko
    Kohno, Michiaki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 433 (04) : 456 - 462
  • [27] CDK1 IS A NOVEL MEDIATOR OF APOPTOSIS RESISTANCE IN BRAF MUTANT COLORECTAL CANCER WHOSE COMBINED ANTAGONISM WITH A MEK/ERK INHIBITOR ENHANCES APOPTOSIS AND TUMOR REGRESSION IN A XENOGRAFT MODEL
    Zhang, Peng
    Kawakami, Hisato
    Liu, Weizhen
    Zeng, Xiangyu
    Stebhardt, Klaus
    Tao, Kaixiong
    Huang, Shengbing
    Sinicrope, Frank A.
    GASTROENTEROLOGY, 2018, 154 (06) : S50 - S50
  • [28] Blockade of the Extracellular Signal-Regulated Kinase Pathway Enhances the Therapeutic Efficacy of Microtubule-Destabilizing Agents in Human Tumor Xenograft Models
    Watanabe, Kazushi
    Tanimura, Susumu
    Uchiyama, Aya
    Sakamoto, Toshiaki
    Kawabata, Takumi
    Ozaki, Kei-ichi
    Kohno, Michiaki
    CLINICAL CANCER RESEARCH, 2010, 16 (04) : 1170 - 1178
  • [29] Administration of the optimized β-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model
    Seoane, Samuel
    Diaz-Rodriguez, Patricia
    Sendon-Lago, Juan
    Gallego, Rosalia
    Perez-Fernandez, Roman
    Landin, Mariana
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 84 (03) : 497 - 504
  • [30] HGS-TR2J, a human, agonistic, TRAIL receptor 2 monoclonal antibody, induces apoptosis in vitro, in vivo tumor regression and growth inhibition in several human tumor cell lines and enhances the anti-tumor activity of platinum and taxane agents in lung and ovarian tumor cell lines
    Humphreys, Robin C.
    Poortman, Carol
    Shepard, Lindsey
    Shields, Elizabeth
    Fiscella, Michele
    Zhang, Lily
    Blondel, Olivier
    McCormick, Kathy
    Johnson, Ron
    Albert, Vivian
    ANNALS OF ONCOLOGY, 2004, 15 : 102 - 103