HGS-TR2J, a human, agonistic, TRAIL receptor 2 monoclonal antibody, induces apoptosis in vitro, in vivo tumor regression and growth inhibition in several human tumor cell lines and enhances the anti-tumor activity of platinum and taxane agents in lung and ovarian tumor cell lines

被引：0
|
作者：
Humphreys, Robin C.
Poortman, Carol
Shepard, Lindsey
Shields, Elizabeth
Fiscella, Michele
Zhang, Lily
Blondel, Olivier
McCormick, Kathy
Johnson, Ron
Albert, Vivian
机构：
来源：
ANNALS OF ONCOLOGY | 2004年 / 15卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：102 / 103
页数：5
相关论文
共 39 条
  • [1] Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo
    Yasuda, Arisa
    Kondo, Seiji
    Nagumo, Tatsuhito
    Tsukamoto, Hikari
    Mukudai, Yoshiki
    Umezawa, Kazuo
    Shintani, Satoru
    ORAL ONCOLOGY, 2011, 47 (05) : 334 - 339
  • [2] Human agonistic anti-TRAIL receptor antibodies, HGS-ETR1 and HGS-ETR2, induce apoptosis in diverse hematological tumor lines.
    Johnson, RL
    Huang, XL
    Fiscella, M
    Cole, C
    Pukac, L
    Von Kerczek, A
    Humphreys, R
    Grzegorzewski, KJ
    Gallant, G
    Albert, V
    BLOOD, 2003, 102 (11) : 891A - 891A
  • [3] LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts
    Li, Jing
    Knee, Deborah A.
    Wang, Youzhen
    Zhang, Qingxiu
    Johnson, Jennifer A.
    Cheng, Jane
    He, Helen
    Miller, Christine
    Li, Zhifang
    Kowal, Colleen
    Eckman, Joseph, III
    Tang, Betty
    Yuan, Jing
    Chen, Liqing
    Deveraux, Quinn
    Nasoff, Marc S.
    Stover, David
    DRUG DEVELOPMENT RESEARCH, 2008, 69 (02) : 69 - 82
  • [4] Novel, agonistic, human anti-TRAIL receptor monoclonal antibodies, HGS-ETR1 and HGS-ETR2, are capable of potently inducing tumor regression and growth inhibition as single agents and in combination with chemotherapeutic agents in models of human NSCLC.
    Humphreys, R
    Shepard, L
    Zhang, YQ
    Huang, X
    Johnson, R
    McCormick, K
    Blondel, O
    Kanakaraj, P
    Grzegorzewski, KG
    Fox, NL
    Albert, V
    CLINICAL CANCER RESEARCH, 2003, 9 (16) : 6157S - 6157S
  • [5] Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo
    Zeng, Y
    Wu, XX
    Fiscella, M
    Shimada, O
    Humphreys, R
    Albert, V
    Kakehi, Y
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2006, 28 (02) : 421 - 430
  • [6] Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo
    Chun-Guang, Wang
    Jun-Qing, Yang
    Bei-Zhong, Liu
    Dan-Ting, Jin
    Chong, Wang
    Liang, Zhong
    Dan, Zhu
    Yan, Wu
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 627 (1-3) : 33 - 41
  • [7] Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines
    Neves, Marta Perro
    Cravo, Sara
    Lima, Raquel T.
    Helena Vasconcelos, M.
    Sao Jose Nascimento, M.
    Silva, Artur M. S.
    Pinto, Madalena
    Cidade, Honorina
    Correa, Arlene G.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (01) : 25 - 33
  • [8] In Vitro Evaluation of the Anti-EGFR Antibody Cetuximab and the Anti-HER2 Antibody Trastuzumab in a Panel of Human Tumor Cell Lines
    Marcoe, K. F.
    Ovechkina, Y.
    Keyser, R.
    Bernards, K.
    Chestnut-Speelman, J.
    Yoshino, K.
    O'Day, C.
    CANCER RESEARCH, 2010, 70
  • [9] THE EVALUATION OF ANTI CANCER ACTIVITY OF ISOTHIOUREA DERIVATIVES AND CK2 INHIBITORS ON CELL LINES OF HUMAN GLIAL TUMOR IN VITRO
    Pucko, E.
    Ostrowski, R.
    Zembrzuska, K.
    Zielinska, M.
    Matyja, E.
    NEURO-ONCOLOGY, 2018, 20 : 290 - 290
  • [10] Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis
    Liu, Yunyi
    Wang, Wei
    Fang, Bin
    Ma, Fengyun
    Zheng, Qian
    Deng, Pengyi
    Zhao, Shasha
    Chen, Mingjie
    Yang, Guangxiao
    He, Guangyuan
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 698 (1-3) : 95 - 102
1234