Efficient synthesis of novel benzo-[e]-[1,4]-diazepine derivatives

被引：11

作者：

Messeri, T ^{[1
]}

Pentassuglia, G ^{[1
]}

Di Fabio, R ^{[1
]}

机构：

[1] Glaxo Wellcome SpA, Med Res Ctr, I-37135 Verona, Italy

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 18期

关键词：

glycine antagonists; synthesis; benzo-[e]-[1,4]-diazepines;

D O I：

10.1016/S0040-4039(01)00402-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Following two efficient synthetic routes a novel series of benzo-[e]-[1,4]-diazepine derivatives, bearing an unusual Z exo-methylencarbamoyl side chain at the C-5 position, have been prepared to identify new antagonists of the glycine binding site associated with NMDA receptor. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：3227 / 3230

页数：4

共 50 条

[41] Synthesis, spectral studies and biological activity of novel 1H-1,4-diazepine derivatives
Kumar, Rajesh
Joshi, Yogesh C.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2010, 49 (01): : 84 - 88
[42] Access to a Diverse Array of Bridged Benzo[1,5]oxazocine and Benzo[1,4]diazepine Structures
Sherborne, Grant J.
Diene, Coura
Kemmitt, Paul
Smith, Andrew D.
ORGANIC LETTERS, 2023, 25 (48) : 8585 - 8589
[43] Synthesis and neurotropic activity of hydrogenated derivatives of quinoxaline and dibenzo[b,f][1,4]diazepine
Krichevskii É.S.
Alekseeva L.M.
Anisimova O.S.
Parshin V.A.
Asnina V.V.
Granik V.G.
Pharmaceutical Chemistry Journal, 1997, 31 (8) : 399 - 402
[44] The synthesis of novel hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives
Chechina, N. V.
Kravchuk, O. F.
Omelchenko, I. V.
Shishkin, O. V.
Kolos, N. N.
ARKIVOC, 2015, : 77 - 91
[45] SYNTHESIS OF DERIVATIVES OF FLUORENO[1,9-EF]-1,4-DIAZEPINE
HROMATKA, O
KNOLLMUL.M
MAIER, KA
MONATSHEFTE FUR CHEMIE, 1967, 98 (03): : 679 - &
[46] Cyclopropanation of 3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-diones
Lack, O
Martin, RE
TETRAHEDRON LETTERS, 2005, 46 (47) : 8207 - 8211
[47] Synthesis of a novel heterocyclic system -: pyrazolo[5,4,3-de]pyrimido[4,5-e]-[1,4]diazepine
Masevicius, V.
Juskenas, R.
Tumkevicius, S.
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2007, (12): : 1878 - 1880
[48] Discovery of novel benzo[b][1,4]oxazine derivatives as ferroptosis inhibitors
Wan, Bi-Wen
Liu, Wei
Xiao, Yijie
Lv, Lijie
Li, Xuan
Lin, Fang
Zhao, Yahui
He, Yi
Nie, Shenyou
Yang, Xiaoyu
Yuan, Hai-Xin
BIOORGANIC CHEMISTRY, 2025, 156
[49] ANALGESIC AND ANTIINFLAMMATORY PROPERTIES OF THE PIROLO-[3,4-E][1,4]-DIAZEPINE DERIVATIVES
STOCHLA, K
DOROCIAK, A
MAKULSKA, HE
POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, 1984, 36 (06): : 665 - 674
[50] Microwave-assisted Synthesis of Benzo-[1,4]-oxazinones Using MeO-PEG-OMe as Solvent
Lim, Jae-Min
Gam, Gyunghee
Kim, Shin-Hyuong
Jang, Kiwan
Shin, Dong-Soo
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE, 2012, 56 (04): : 468 - 472

← 1 2 3 4 5 →