Efficient synthesis of novel benzo-[e]-[1,4]-diazepine derivatives

被引：11
|
作者：
Messeri, T [1 ]
Pentassuglia, G [1 ]
Di Fabio, R [1 ]
机构：
[1] Glaxo Wellcome SpA, Med Res Ctr, I-37135 Verona, Italy
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 18期
关键词：
glycine antagonists; synthesis; benzo-[e]-[1,4]-diazepines;
D O I：
10.1016/S0040-4039(01)00402-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Following two efficient synthetic routes a novel series of benzo-[e]-[1,4]-diazepine derivatives, bearing an unusual Z exo-methylencarbamoyl side chain at the C-5 position, have been prepared to identify new antagonists of the glycine binding site associated with NMDA receptor. (C) 2001 Published by Elsevier Science Ltd.
引用
收藏
页码：3227 / 3230
页数：4
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