Rapidly progressing bilateral cataracts in a patient with beta thalassemia and pellagra

被引：8
|
作者：
Athanasiadis, Ioannis
Konstantinidis, Aristeidis
Kyprianou, Ioannis
Robinson, Rosemary
Moschou, Vaia
Kouzi-Koliakos, Kokkona
机构：
[1] Coventry & Warwickshire Univ Hosp NHS Trust, Dept Ophthalmol, Walsgrave Hosp, Coventry, W Midlands, England
[2] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Thessaloniki, Greece
来源：
JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 2007年 / 33卷 / 09期
关键词：
D O I：
10.1016/j.jcrs.2007.05.011
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Soon after the diagnosis of pellagra in a 20-year-old patient with beta thalassemia, bilateral intumescent cataracts rapidly developed. We believe the patient's crystalline lenses were at an increased oxidative state due to iron overload from the thalassemia. Depletion of the lens epithelial cells of an important antioxidative agent (glutathione) as a result of niacin (vitamin B3) deficiency due to pellagra reduced the antioxidative capacity of the lenses. The oxidative damage led to rapid development of cataracts.
引用
收藏
页码：1659 / 1661
页数：3
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