A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real-Time Tumor-Tracking and Photothermal-Enhanced Chemotherapy

被引：26
|
作者：
Sun, Tao [1 ,2 ]
Zhang, Guangping [3 ,4 ]
Ning, Tingting [1 ,2 ]
Chen, Qinjun [1 ,2 ]
Chu, Yongchao [1 ,2 ]
Luo, Yifan [1 ,2 ]
You, Haoyu [1 ,2 ]
Su, Boyu [1 ,2 ]
Li, Chao [1 ,2 ]
Guo, Qin [1 ,2 ]
Jiang, Chen [1 ,2 ]
机构：
[1] Fudan Univ, Sch Pharm,Minhang Hosp, Dept Pharmaceut,Key Lab Smart Drug Delivery,Minis, Inst Brain Sci,State Key Lab Med Neurobiol, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
[2] Fudan Univ, MOE Frontiers Ctr Brain Sci, Inst Brain Sci, Dept Pharmaceut,Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
[3] Shandong Normal Univ, Sch Phys & Elect, Shandong Prov Key Lab Med Phys & Image Proc Techn, 1 Univ Rd, Shandong 250358, Peoples R China
[4] Shandong Normal Univ, Inst Mat & Clean Energy, 1 Univ Rd, Shandong 250358, Peoples R China
来源：
ADVANCED SCIENCE | 2021年 / 8卷 / 20期
基金：
国家重点研发计划;
关键词：
colorectal cancer peritoneal metastases; hyperthermic intraperitoneal chemotherapy; photothermal; theranostic; tumor tracking; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; SULFUR-DIOXIDE; CARCINOMATOSIS; NANOMEDICINE;
D O I：
10.1002/advs.202102256
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A versatile tumor-targeting stimuli-responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal-enhanced chemotherapy. A quenched photosensitizer ("off" state) is developed and escorted into a tumor-targeting oxaliplatin-embedded micelle. Once reaching the tumor cell, the micelle is clasped to release free oxaliplatin, as well as the "off" photosensitizer, which is further activated ("turned-on") in the tumor reducing microenvironment to provide optical imaging and photothermal effect. The combined results from hyperthermia-enhanced chemotherapy, deep penetration, perfused O-2, and the leveraged GSH-ROS imbalance in tumor cells are achieved for improved antitumor efficacy and reduced systematic toxicity.
引用
收藏
页数：17
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