New β-amino thiols as efficient catalysts for highly enantioselective alkenylzinc addition to aldehydes

被引：33
|
作者：
Tseng, SL [1 ]
Yang, TK [1 ]
机构：
[1] Natl Chung Hsing Univ, Dept Chem, Taichung 40227, Taiwan
来源：
TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 04期
关键词：
D O I：
10.1016/j.tetasy.2004.11.093
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of new optically active beta-amino thiols and thiolacetates prepared from the simple natural amino acid, (S)-(-)-valine, were found to be effective catalysts for the enantioselective addition of alkenylzinc to alclehydes and thereby providing an efficient route for chiral (E)-allylic alcohols with ees of up to >99% in the presence of 7a (1 mol %). (C) 2005 Published by Elsevier Ltd.
引用
收藏
页码：773 / 782
页数：10
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